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Thermo Scientific Toluene-α-sulphonyl fluoride 99%
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Specifications:
| Application | molecular biology, Proteomics | ||
| Storage Temperature | Ambient | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology, Analytical grade | Formula | C₇H₇FO₂S |
Thermo Scientific™ Toluene-α-sulphonyl Fluoride 99%, commonly known as PMSF (Phenylmethylsulphonyl Fluoride), is a high-purity chemical widely used as a serine protease inhibitor in biochemical and proteomics workflows. It is essential for protecting proteins from enzymatic degradation during cell lysis, extraction, and purification processes.
Supplied as a high-quality crystalline solid, this reagent ensures consistent performance in laboratory applications requiring precise and reliable protease inhibition.
Key Features
High Purity and Quality
- Purity ≥98.5% (GC)
- Verified identity via infrared spectrum
- Consistent melting point (90–94 °C)
Effective Protease Inhibition
- Inhibits serine proteases such as trypsin, chymotrypsin, and thrombin
- Also affects certain cysteine proteases under specific conditions
- Widely used in protein stabilization workflows
Reliable Chemical Properties
- Stable crystalline form (white needles or agglomerates)
- Well-defined physicochemical characteristics
- Suitable for controlled laboratory applications
Flexible Laboratory Use
- Compatible with protein extraction and purification workflows
- Easily prepared into stock solutions for immediate use
- Suitable for biochemical, enzymatic, and proteomics studies
Applications
- Protein extraction and cell lysis workflows
- Proteomics and protein stability studies
- Enzyme inhibition and biochemical research
- Laboratory research involving protease activity
- Molecular biology and life science applications
Technical Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | Toluene-α-sulphonyl Fluoride (PMSF) |
| Synonyms | Phenylmethylsulphonyl fluoride, α-Toluenesulphonyl fluoride |
| CAS Number | 329-98-6 |
| Molecular Formula | C₇H₇FO₂S |
| Molecular Weight | 174.2 g/mol |
| Purity (GC) | ≥98.5% |
| Appearance | White needles or agglomerates |
| Melting Point | 90–94 °C |
| Boiling Point | 80–85 °C (reduced pressure) |
| Storage Temperature | Ambient |
| EINECS | 206-350-2 |
| UN Number | 2923 |
| ADR Classification | 8, II |
Hazard Information
- Toxic
- Corrosive
Appropriate safety precautions, including use of PPE and handling in a controlled environment, are required. Refer to the Safety Data Sheet (SDS) for full safety guidance.
Product Options
| Cat. No. | Pack Size | Packaging |
|---|---|---|
| 215740010 | 1 g | Glass bottle |
| 215740050 | 5 g | Glass bottle |
| 215740100 | 10 g | Glass bottle |
| 215740500 | 50 g | Glass bottle |
Quality Compliance
- Confirmed by infrared spectroscopy
- Controlled melting point and purity specifications
- Supplied with SDS and Certificate of Analysis (where applicable)
Thermo Scientific™ Toluene-α-sulphonyl Fluoride 99% (PMSF) is a trusted and widely used reagent for selective protease inhibition in laboratory workflows. Its high purity, defined properties, and reliable performance make it an essential chemical for protein research and biochemical applications.
- Pack Size: 1g 5g 10g 50g