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Thermo Scientific™ Ceftriaxone Sodium Salt Hemiheptahydrate
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Specifications:
| Application | Cell culture | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Antibiotic | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Cell Culture | Formula | C₃₆H₄₆N₁₆Na₄O₂₁S₆ |
High-Purity Third-Generation Cephalosporin Antibiotic – Research Grade
Thermo Scientific™ Ceftriaxone Sodium Salt Hemiheptahydrate is a broad-spectrum, third-generation cephalosporin antibiotic supplied as the sodium salt in its hemiheptahydrate form. It is effective against a wide range of gram-negative bacterial pathogens and is commonly used in microbiological, pharmacological, and biochemical studies. This compound acts by inhibiting penicillin-binding proteins (PBPs), leading to impaired bacterial cell wall synthesis and cell lysis.
Key Features and Benefits
-
Beta-Lactam Cephalosporin Antibiotic
Disrupts bacterial cell wall synthesis by targeting penicillin-binding proteins. -
High Purity
HPLC purity ≥94%; suitable for biochemical assays and in vitro microbiological applications. -
Well-Characterized Solid Form
Supplied as a crystalline powder; conforms to expected IR spectrum, with moisture content ≤10%. -
Research Use Only
Not for clinical or therapeutic use in humans or animals.
Applications
- Inhibition of peptidoglycan synthesis via PBP inactivation
- Antibiotic activity profiling in gram-negative bacterial cultures
- Drug resistance and pharmacokinetic studies in beta-lactam susceptibility testing
- Comparative antibiotic efficacy assays (e.g., against gentamicin in clinical research)
Chemical Properties
| Property | Value |
|---|---|
| Chemical Name | Ceftriaxone sodium salt hemiheptahydrate |
| CAS Number | 104376-79-6 |
| Molecular Formula | C₃₆H₄₆N₁₆Na₄O₂₁S₆ |
| Molecular Weight | 1323.17 g/mol |
| Synonyms | Ceftriaxone Na hemiheptahydrate, Ceftriaxone sodium |
| IUPAC Name | See long IUPAC name in original listing |
| Appearance | White to light yellow crystalline powder |
| Melting Point | Not specified |
| Boiling Point | Not applicable |
| Density | Not specified |
| Water Content | ≤10% |
| Purity (HPLC) | ≥94% |
| Storage Conditions | Ambient |
| Shipping Conditions | Room temperature |
Available Pack Sizes
| Catalog Number | Pack Size | Format | |
|---|---|---|---|
| 455420010 | 1 g | Bottle | |
| 455420050 | 5 g | Bottle | |
| 455420250 | 25 g | Bottle |
Handling and Safety
- Classified under UN3077 (Environmentally hazardous substance, solid, n.o.s.)
- Use appropriate PPE when handling.
- Refer to SDS for detailed safety precautions.
Supporting Literature
- Grégoire et al., High-Dose Ceftriaxone for Bacterial Meningitis, Antimicrob. Agents Chemother., 2019.
- Ross et al., G-ToG: Gentamicin vs Ceftriaxone for Gonorrhoea, Lancet, 2019.
Thermo Scientific™ Ceftriaxone Sodium Salt Hemiheptahydrate provides researchers with a high-purity, research-grade form of a clinically significant cephalosporin antibiotic. It is an ideal reagent for antimicrobial susceptibility studies, resistance mechanism evaluations, and microbiological pharmacodynamics research.
- Pack Size: 1g 5g 25g