Thermo Scientific™ Ceftriaxone Sodium Salt Hemiheptahydrate

High-Purity Third-Generation Cephalosporin Antibiotic – Research Grade

Thermo Scientific™ Ceftriaxone Sodium Salt Hemiheptahydrate is a broad-spectrum, third-generation cephalosporin antibiotic supplied as the sodium salt in its hemiheptahydrate form. It is effective against a wide range of gram-negative bacterial pathogens and is commonly used in microbiological, pharmacological, and biochemical studies. This compound acts by inhibiting penicillin-binding proteins (PBPs), leading to impaired bacterial cell wall synthesis and cell lysis.

Key Features and Benefits

• Beta-Lactam Cephalosporin Antibiotic
  Disrupts bacterial cell wall synthesis by targeting penicillin-binding proteins.
• High Purity
  HPLC purity ≥94%; suitable for biochemical assays and in vitro microbiological applications.
• Well-Characterized Solid Form
  Supplied as a crystalline powder; conforms to expected IR spectrum, with moisture content ≤10%.
• Research Use Only
  Not for clinical or therapeutic use in humans or animals.

Applications

• Inhibition of peptidoglycan synthesis via PBP inactivation
• Antibiotic activity profiling in gram-negative bacterial cultures
• Drug resistance and pharmacokinetic studies in beta-lactam susceptibility testing
• Comparative antibiotic efficacy assays (e.g., against gentamicin in clinical research)

Chemical Properties

Available Pack Sizes

Handling and Safety

• Classified under UN3077 (Environmentally hazardous substance, solid, n.o.s.)
• Use appropriate PPE when handling.
• Refer to SDS for detailed safety precautions.

Supporting Literature

• Grégoire et al., High-Dose Ceftriaxone for Bacterial Meningitis, Antimicrob. Agents Chemother., 2019.
• Ross et al., G-ToG: Gentamicin vs Ceftriaxone for Gonorrhoea, Lancet, 2019.

Thermo Scientific™ Ceftriaxone Sodium Salt Hemiheptahydrate provides researchers with a high-purity, research-grade form of a clinically significant cephalosporin antibiotic. It is an ideal reagent for antimicrobial susceptibility studies, resistance mechanism evaluations, and microbiological pharmacodynamics research.