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Thermo Scientific™ Mitomycin C, from Streptomyces caespitosus
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contains 2 mg Mitomycin C and 48 mg NaCl
Specifications:
| Application | cell Signalling | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Antibiotic, Biochemical Reagent | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₁₅H₁₈N₄O₅ |
Thermo Scientific™ Mitomycin C is a naturally derived antitumor antibiotic produced by Streptomyces caespitosus and related Streptomyces species.
It functions as a bioreductive alkylating agent that, upon reduction, forms reactive oxygen radicals and induces DNA crosslinks, leading to the inhibition of DNA synthesis and cell proliferation.
With strong antineoplastic and antimicrobial properties, Mitomycin C is preferentially cytotoxic to hypoxic tumor cells that are resistant to conventional therapies, making it an essential tool in oncology, pharmacology, and molecular biology research.
Key Features
- High Purity: ≥99% (HPLC, relative to non-formulated material).
- Potent DNA Crosslinker: Alkylates and crosslinks DNA, inhibiting synthesis and cell division.
- Bioreductive Agent: Generates reactive oxygen species (ROS) under hypoxic conditions.
- Selective Antitumor Activity: Cytotoxic to hypoxic tumor cells resistant to radiotherapy and chemotherapy.
- Antimicrobial Properties: Inhibits RNA and protein synthesis in Gram-positive and Gram-negative bacteria at high concentrations.
- Research Grade: For mechanistic studies on DNA damage, repair, and cancer cell response.
- Storage: Stable at 2–8 °C; light and acid sensitive.
- Research Use Only (RUO): Not for diagnostic or therapeutic use.
Chemical Identifiers
| Property | Value |
|---|---|
| Chemical Name (IUPAC) | [(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.0²,⁷.0⁴,⁶]trideca-1(9),11-dien-8-yl]methyl carbamate |
| Synonyms | Mitomycin C, MMC, Mitocin C, Mitozytrex, Mitomycine-C |
| CAS Number | 50-07-7 |
| Molecular Formula | C₁₅H₁₈N₄O₅ |
| Molecular Weight | 334.32 g/mol |
| InChI Key | NWIBSHFKIJFRCO-WUDYKRTCSA-N |
| SMILES | CO[C@]12[C@H]3N[C@H]3CN1C1=C([C@H]2COC(N)=O)C(=O)C(N)=C(C)C1=O |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | ≥99% |
| Form | Powder |
| Appearance | Grey to blue crystalline powder |
| Stability | Light and acid sensitive |
| Solubility | Water soluble |
| Storage Conditions | 2–8 °C; protect from light and moisture |
| Packaging | Glass vial with NaCl stabilizer |
| Composition | 2 mg Mitomycin C + 48 mg NaCl |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer Research: Studies on DNA crosslinking, oxidative stress, and hypoxia-induced cytotoxicity.
- DNA Repair and Genotoxicity Studies: Investigation of double-strand break repair pathways.
- Pharmacology: Analysis of Mitomycin C’s selective toxicity and bioreductive activation.
- Microbiology: Evaluation of antibacterial activity against Gram-positive and Gram-negative strains.
- Ophthalmology: Research on corneal refractive surgery wound healing (Mitomycin C modulation).
References
- Verweij, J. & Pinedo, H.M. “Mitomycin C: Mechanism of Action, Usefulness, and Limitations.” Anticancer Drugs (1990) 1(1), 5–13.
- Tomasz, M. “Mitomycin C: Small, Fast, and Deadly (But Very Selective).” Chem. Biol. (1995) 2(9), 575–579.
- Teus, M.A. et al. “Mitomycin C in Corneal Refractive Surgery.” Surv. Ophthalmol. (2009) 54(4), 487–502.
Safety & Handling
- Signal Word: Warning
-
Hazard Statements:
- H302 – Harmful if swallowed
- H351 – Suspected of causing cancer
-
Precautionary Statements:
- P201 – Obtain special instructions before use
- P280 – Wear protective gloves/protective clothing/eye protection
- P308 + P313 – If exposed or concerned, seek medical advice
- P301 + P312 – If swallowed: Call a POISON CENTER or physician
- Classification: Acute Oral Toxicity Cat. 4 | Carcinogenicity Cat. 2
The Thermo Scientific™ Mitomycin C (2 mg Mitomycin C + 48 mg NaCl) is a high-purity antitumor antibiotic that functions as a bioreductive DNA crosslinking agent.
It is a versatile compound for DNA damage, hypoxia, and cancer resistance studies, offering consistent Thermo Scientific quality for oncology, pharmacology, and molecular biology research.