Thermo Scientific™ Pefloxacine methanesulphonate dihydrate 95%

Thermo Scientific™ Pefloxacin Methanesulphonate Dihydrate is a synthetic, broad-spectrum fluoroquinolone antibiotic used in microbiological research and pharmaceutical development. Known for its potent activity against a wide range of Gram-negative and Gram-positive bacteria, it is structurally related to norfloxacin and functions by targeting DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication and transcription.

Key Features

• High Purity (≥95%) – Suitable for microbiological assays and biochemical research
• Mechanism of Action – Inhibits DNA gyrase (Gram-negative target) and topoisomerase IV (Gram-positive target), disrupting DNA synthesis
• Broad Antibacterial Activity – Effective against E. coli, Staphylococcus aureus, Pseudomonas aeruginosa, and other enterobacteria
• Research Validated – Commonly used in toxicity models and hepatocyte uptake studies
• Analog of Norfloxacin – Shares similar activity with structural differences improving pharmacokinetics

Biochemical / Physiological Actions

• Inhibition of DNA Supercoiling – Leads to irreversible DNA strand breakage in bacteria
• Prevents Transcription and Replication – Blocking of bacterial proliferation
• Cytotoxicity Studies – Useful for assessing toxicity mechanisms in rodent and hepatocyte models
• Antimicrobial Research – Tool for screening antibiotic resistance and mechanisms of action

Applications

• Microbiology Research – Study of bacterial inhibition mechanisms
• Pharmacology & Toxicology – Used to induce Achilles tendon toxicity in rodent models
• Cellular Studies – Investigates cytotoxicity and drug uptake in hepatocytes
• Antibiotic Resistance Research – Fluoroquinolone model for evaluating resistance pathways

Storage & Handling

• Store in a dry, well-ventilated place
• Keep the container tightly closed to avoid degradation
• Avoid exposure to moisture and direct sunlight

Chemical Identifiers

Thermo Scientific™ Pefloxacin Methanesulphonate Dihydrate (95%) is a reliable tool for antimicrobial research and cellular studies, offering well-characterized inhibitory activity against critical bacterial targets. Its defined purity and established efficacy make it a valuable asset in fluoroquinolone research and pharmacological development.