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Thermo Scientific™ Pefloxacine methanesulphonate dihydrate 95%
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Specifications:
| Application | Microbiology | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Antibiotic | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₁₇H₂₀FN₃O₃·CH₄O₃S·2H₂O |
Thermo Scientific™ Pefloxacin Methanesulphonate Dihydrate is a synthetic, broad-spectrum fluoroquinolone antibiotic used in microbiological research and pharmaceutical development. Known for its potent activity against a wide range of Gram-negative and Gram-positive bacteria, it is structurally related to norfloxacin and functions by targeting DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication and transcription.
Key Features
- High Purity (≥95%) – Suitable for microbiological assays and biochemical research
- Mechanism of Action – Inhibits DNA gyrase (Gram-negative target) and topoisomerase IV (Gram-positive target), disrupting DNA synthesis
- Broad Antibacterial Activity – Effective against E. coli, Staphylococcus aureus, Pseudomonas aeruginosa, and other enterobacteria
- Research Validated – Commonly used in toxicity models and hepatocyte uptake studies
- Analog of Norfloxacin – Shares similar activity with structural differences improving pharmacokinetics
Biochemical / Physiological Actions
- Inhibition of DNA Supercoiling – Leads to irreversible DNA strand breakage in bacteria
- Prevents Transcription and Replication – Blocking of bacterial proliferation
- Cytotoxicity Studies – Useful for assessing toxicity mechanisms in rodent and hepatocyte models
- Antimicrobial Research – Tool for screening antibiotic resistance and mechanisms of action
Applications
- Microbiology Research – Study of bacterial inhibition mechanisms
- Pharmacology & Toxicology – Used to induce Achilles tendon toxicity in rodent models
- Cellular Studies – Investigates cytotoxicity and drug uptake in hepatocytes
- Antibiotic Resistance Research – Fluoroquinolone model for evaluating resistance pathways
Storage & Handling
- Store in a dry, well-ventilated place
- Keep the container tightly closed to avoid degradation
- Avoid exposure to moisture and direct sunlight
Chemical Identifiers
| Property | Value |
|---|---|
| Compound Name | Pefloxacin Methanesulphonate Dihydrate |
| Synonyms | Pefloxacin mesylate dihydrate |
| Chemical Class | Fluoroquinolone antibiotic |
| Purity | ≥95% |
| Mode of Action | DNA gyrase/topoisomerase IV inhibition |
| Antimicrobial Spectrum | Broad-spectrum: Gram-positive and Gram-negative bacteria |
Thermo Scientific™ Pefloxacin Methanesulphonate Dihydrate (95%) is a reliable tool for antimicrobial research and cellular studies, offering well-characterized inhibitory activity against critical bacterial targets. Its defined purity and established efficacy make it a valuable asset in fluoroquinolone research and pharmacological development.