Thermo Scientific™ Vanquish™ Diode Array Detector (DAD) FG

The Thermo Scientific™ Vanquish™ Diode Array Detector FG (DAD FG) delivers advanced optical performance, exceptional wavelength coverage, and outstanding sensitivity for HPLC and UHPLC applications. With a broad wavelength range of 190–800 nm, this detector extends beyond typical UV-Vis detection, enabling analysis of analytes absorbing in both the deep-UV and visible range.

The FG model belongs to the Vanquish family of premium detection modules designed to deliver high linearity, low noise, and reliable peak integration across routine, research, and regulatory chromatography workflows. Built with state-of-the-art photodiode array technology and powerful acquisition electronics, it supports ultrafast separations, spectral analysis, peak purity assessment, and quantification of trace impurities.

Key Performance Features

1. Extended Wavelength Range (190–800 nm)

• Enables UV and visible-range detection
• Ideal for analyzing chromophores, colored compounds, and biomolecules
• Supports spectral fingerprinting and peak purity analysis

This broad range makes the DAD FG suitable for pharmaceutical, biopharmaceutical, environmental, food, and industrial applications.

2. Fast Data Acquisition for UHPLC

• Up to 250 Hz sampling rate
• Supports narrow peak widths from ultrafast separations
• Records 10 absorbance channels plus 3D spectral field simultaneously
• Ensures accurate quantification and robust resolution during high-throughput workflows

3. High Linearity and Ultra-Wide Dynamic Range

• < 5% deviation at 2.2 AU (typically <5% up to 2.7 AU)
• Enables quantification of main analytes and trace impurities in a single injection
• Reduces need for repeat analyses or dilution steps

4. Flow Cell Versatility for All Applications

Includes multiple interchangeable flow cells designed to match different workflows:

• Standard 10 mm, 13 µL (SST)
• Standard 10 mm, 13 µL biocompatible (PEEK)
• Semi-analytical 7 mm, 5 µL (SST)
• Semi-micro 7 mm, 2.5 µL (SST)
• Semi-micro biocompatible 7 mm, 2.5 µL (titanium)
• Diagnostic cell for performance verification

These flow cell options support applications ranging from low-dispersion UHPLC to biocompatible LC-MS workflows.

5. Low Noise and Excellent Stability

• Noise < ±6 μAU at 254 nm
• Drift < 1 mAU/hour
• Stable baselines for precise peak integration
• Reliable performance during long sequences and QC batch runs

6. GLP-Compliant Design

The detector integrates advanced laboratory compliance features:

• Lamp age & ignition monitoring
• Lamp intensity degradation tracking
• Leak detection and safe leak handling
• Automatic power-up diagnostics (optics, cooling, electronics)
• Full logging in Chromeleon™ CDS audit trail

These features support regulated environments and method lifecycle management.

7. Dual-Lamp Optical System

• Deuterium lamp for UV range
• Tungsten lamp for visible wavelengths
• Provides stable illumination across 190–800 nm spectrum

Applications

• UHPLC and HPLC UV–Vis detection
• Pharmaceutical impurity profiling
• Peak purity and spectral confirmation
• Biopharmaceutical characterization
• Environmental contaminant analysis
• Food and beverage quality testing
• Colorimetric compound analysis
• High-speed UHPLC separations

Specifications

The Thermo Scientific™ Vanquish™ Diode Array Detector FG delivers broad wavelength coverage (190–800 nm), fast acquisition (250 Hz), multiple flow cell options, and exceptional linearity. Ideal for UHPLC workflows requiring high sensitivity, spectral flexibility, and compliance-ready performance.