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Thermo Scientific™ Proguanil hydrochloride 97%
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Formula: C₁₁H₁₆ClN₅·HCl
CAS Number: 637-32-1
Specifications:
| Application | molecular biology | ||
| Storage Temperature | Ambient | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | NH₂C(=NH)NH₂·HCl |
Thermo Scientific™ Proguanil Hydrochloride, 97%, is a pharmaceutical-grade compound widely used in antimalarial research and drug development. This white to off-white crystalline powder is a hydrochloride salt form of proguanil, a dihydrofolate reductase (DHFR) inhibitor that exerts its antiprotozoal effect by interfering with the folate cycle in Plasmodium spp., the causative agent of malaria.
The compound is suitable for research applications including bioassays, drug metabolism, and pharmacokinetics studies. Supplied with ≥96% purity (by HPLC) and IR spectrum confirmation, it meets stringent analytical standards for reproducibility in both analytical and pharmaceutical investigations.
Key Features & Benefits
- High Purity: ≥96% (HPLC) ensures consistent performance in sensitive assays
- Defined Identity: Verified by infrared (IR) spectroscopy
- Research-Grade: Supplied in a stable crystalline form for lab-based applications
- Low Moisture Content: ≤0.5% loss on drying, ensuring sample stability
- Reliable Sourcing: From the Thermo Scientific™ / Acros Organics portfolio
Applications
- Antimalarial pharmacology and drug mechanism studies
- DHFR inhibitor screening and resistance research
- Biotransformation to cycloguanil for metabolic pathway analysis
- Reference standard in chromatographic and spectroscopic assays
- Use in in vitro parasite growth inhibition assays
Specifications
| Attribute | Value |
|---|---|
| Chemical Name | Proguanil Hydrochloride |
| Synonyms | Hydrogen proguanil chloride |
| Purity (HPLC) | ≥96.0% |
| Appearance | White to off-white crystalline powder |
| Loss on Drying | ≤0.5% |
| Form | Solid |
| Melting Point (approx) | 165–170 °C (literature reference) |
| Storage | Room temperature, protected from moisture |
| Use | Research Use Only (RUO) |
Ordering Information
| Catalog Number | Quantity | Packaging |
|---|---|---|
| 461430250 | 25 mg | Glass bottle |
| 461431000 | 100 mg | Glass bottle |
Thermo Scientific™ Proguanil Hydrochloride, 97% offers pharmaceutical researchers and academic scientists a high-purity compound for antimalarial research and related biological studies. Its consistent quality, proven performance, and compliance with analytical standards make it a dependable choice for demanding applications in malaria drug development.
- Pack Size: 100mg 25 mg