Thermo Scientific™ Hydroxyurea, 98%

DNA Synthesis Inhibitor and Pharmaceutical Intermediate for Research Applications

Thermo Scientific™ Hydroxyurea is a high-purity reagent-grade compound with a minimum assay of 98%. This crystalline or powdered chemical is widely used in molecular biology, oncology, and hematology research due to its potent inhibitory effects on DNA synthesis. Hydroxyurea serves as a valuable tool for researchers studying cell cycle regulation, anticancer mechanisms, antiviral therapies, and sickle cell disease.

Available in multiple pack sizes (1 g, 5 g, 25 g, and 100 g), Hydroxyurea is ideal for both small-scale laboratory studies and scale-up applications. Supplied in moisture-sensitive, airtight containers, it ensures consistent quality and stability during storage and use.

Key Features and Benefits

• Research-Grade Purity:
  ≥98% assay (HPLC), with full conformity by FTIR and proton NMR for structural identity.
• Broad Research Applications:
  Commonly used in studies of DNA replication, anticancer drug development, and sickle cell anemia therapy.
• Pharmaceutical Relevance:
  Investigated for its clinical use in melanoma, chronic myelocytic leukemia, and ovarian cancer, as well as anti-retroviral activity in HIV/AIDS research.
• Solubility Profile:
  Soluble in water, hot alcohol, and DMSO. Insoluble in ethanol and benzene—suitable for aqueous and polar organic systems.
• Convenient Packaging Options:
  Offered in 1 g, 5 g, 25 g, and 100 g glass bottle formats for flexibility in research scale.

Applications

• Inhibition of ribonucleotide reductase for DNA synthesis studies
• Precursor in synthetic pathways (e.g., pyrimidine derivatives)
• Cell cycle arrest experiments (G1/S transition)
• Investigation of cytotoxicity and anticancer effects
• Sickle cell disease research and hemoglobin modulation
• Antiviral research involving HIV-1 replication inhibition
• Model compound for studying oxidative stress and genotoxicity

Chemical and Physical Properties

Safety and Regulatory Information

• Hazard Classification: May cause harm if inhaled, ingested, or absorbed through the skin. Handle with appropriate PPE.
• Storage: Store in a cool, dry place, tightly closed, away from incompatible materials.
• Regulatory Note: May require additional compliance documentation upon order, depending on jurisdiction.
• Intended Use: For Research Use Only. Not intended for human or veterinary diagnostic or therapeutic use.

Ordering Information

Thermo Scientific™ Hydroxyurea, 98% provides a reliable, research-grade solution for scientists investigating DNA synthesis inhibition, cancer biology, and antiviral therapies. With well-documented chemical and biological properties, it is a trusted tool in academic, clinical, and pharmaceutical research.