Thermo Scientific™ Cefsulodin Sodium Salt, 50 mg/mL Solution in Distilled Water, Sterile-Filtered

Cefsulodin sodium salt is a third-generation cephalosporin (β-lactam) antibiotic formulated here as a ready-to-use, sterile-filtered solution at 50 mg/mL in distilled water. It is primarily used in microbiology for the selective isolation of Yersinia spp., particularly in CIN (Cefsulodin–Irgasan–Novobiocin) agar, and for research into antimicrobial resistance.

Cefsulodin acts by inhibiting bacterial cell wall synthesis, targeting penicillin-binding proteins (PBPs), especially PBP1A, PBP1B, and PBP3, and disrupting the transpeptidation step of peptidoglycan crosslinking. This mechanism is characteristic of β-lactam antibiotics and makes the compound particularly effective for microbiological selection and susceptibility studies.

Applications

• Selective Agent in Microbiological Media
  Used in CIN agar for isolation of Yersinia enterocolitica, suppressing background flora in environmental and clinical samples.
• Antimicrobial Resistance Studies
  Supports research on β-lactam resistance mechanisms, including resistance in Pseudomonas aeruginosa and other Gram-negative bacteria.
• Penicillin-Binding Protein Interaction Research
  Useful in studies examining cephalosporin interaction with PBPs involved in bacterial cell wall biosynthesis.
• Convenient Ready-to-Use Format
  Supplied as a pre-dissolved, sterile-filtered solution for direct incorporation into culture media or experimental workflows.

Key Features and Benefits

• Pre-formulated 50 mg/mL aqueous solution for convenience and reproducibility
• Sterile-filtered for direct use in sensitive microbiological and cell culture applications
• Beta-lactam antibiotic activity with high specificity for Gram-negative selection
• Research Use Only (RUO) — not for diagnostic or therapeutic use in humans or animals
• Water-soluble for easy mixing into growth media or experimental buffers

Chemical & Physical Properties

Packaging Information

Safety & Regulatory Information

• GHS Hazard Statements:
  • H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled
  • H317: May cause allergic skin reaction
  • H335: May cause respiratory irritation
• Regulatory Use: Research Use Only (RUO) – not intended for human or veterinary therapeutic or diagnostic use
• Handling: Use appropriate PPE. Refer to SDS for hazard and precautionary information.

Thermo Scientific™ Cefsulodin Sodium Salt, 50 mg/mL in distilled water, offers a sterile, ready-to-use format of a narrow-spectrum cephalosporin antibiotic commonly used in selective microbiology and antimicrobial research. Its well-characterized activity against specific Gram-negative organisms such as Yersinia enterocolitica makes it ideal for selective culture workflows and studies on β-lactam resistance mechanisms.