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Specifications:
| Application | cell Signalling | ||
| Storage Temperature | Room Temperature | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₁₈H₂₄O₂ |
17β-Estradiol is the most potent and predominant form of natural estrogen hormone secreted by the ovary in premenopausal females. It plays a central role in reproductive development, female secondary sex characteristics, menstrual cycle regulation, and gonadotropin feedback mechanisms. This compound is widely used in research involving hormonal regulation, reproductive physiology, and endocrine-disrupting chemicals (EDCs).
Thermo Scientific provides ≥97.5% HPLC-pure 17β-Estradiol as a white to off-white crystalline powder, validated by infrared spectrum and specific optical rotation.
Available Pack Sizes
| Catalog Number | Pack Size | Container Type |
|---|---|---|
| 436320050 | 5 g | Glass bottle |
| 436320250 | 25 g | Glass bottle |
Chemical and Physical Specifications
| Property | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Melting Point | 173–179 °C (literature: 176–180 °C) |
| Water Content | ≤3.5% |
| HPLC Purity | ≥97.5% |
| Infrared Spectrum | Conforms to reference |
| Specific Optical Rotation | +76° to +83° (20 °C, 589 nm, c = 1 in dioxane) |
Applications in Research
17β-Estradiol is widely used in:
-
Reproductive and Fertility Studies
- Supplement for in vitro maturation (IVM) of bovine cumulus-oocyte complexes (COCs)
- Component in oocyte culture and embryo development media
-
Endocrinology and Hormone Replacement Research
- Used in estrogen-induction assays and hormone-regulated gene expression studies
-
Toxicology and Oncology
- Investigation of estrogen receptor (ER)-mediated proliferation, especially in breast cancer cell models
-
Neurobiology
- Studies on neuroprotective effects and estrogen-mediated signaling in the brain
Biological and Physiological Role
- Primary Estrogen: Secreted predominantly by the ovarian granulosa cells
- Hormonal Function: Regulates transcriptional activity, influences protein synthesis, and stimulates ovulation via gonadotropin production
- Developmental Role: Critical for sexual differentiation, pubertal maturation, and menstrual cycle control
- Oncological Implications: Chronic estradiol exposure is associated with increased breast cancer risk and progression
Preparation & Handling
- Solubility: Slightly soluble in water; soluble in ethanol, DMSO, and methanol
- Storage: Stable at room temperature; protect from light and moisture
- Note: Prepare solutions fresh or store aliquots frozen to prevent degradation
Thermo Scientific™ 17β-Estradiol (≥97.5%) is a research-grade estrogen ideal for investigating hormonal mechanisms across developmental biology, reproductive physiology, oncology, and endocrine disruption studies. Backed by high purity and validated spectroscopic data, this compound is an essential standard for laboratories studying estrogen receptor signaling, female reproductive health, and hormone-mediated gene regulation.
- Pack Size: 5g 25g