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Fmoc-Val-OH, also known as Fmoc-L-Valine, is a high-purity, N-protected amino acid derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group, allowing selective deprotection and controlled stepwise peptide elongation.
Valine is a branched-chain hydrophobic amino acid that contributes to protein folding, peptide stability, hydrophobic interactions, and secondary structure formation. Fmoc-Val-OH is therefore an important building block for custom peptide synthesis, pharmaceutical research, drug discovery, proteomics, enzyme-substrate studies, protein engineering, and bioconjugation applications.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| Valine Building Block | Enables incorporation of valine residues into synthetic peptides |
| Hydrophobic Amino Acid | Supports peptide folding, protein stability, and hydrophobic interactions |
| SPPS Compatible | Suitable for solid-phase peptide synthesis and peptide modification |
| Research Applications | Ideal for peptide chemistry, pharmaceutical research, proteomics, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Val-OH, ≥98.0% HPLC |
| Synonym | Fmoc-L-Valine |
| CAS Number | 68858-20-8 |
| Empirical Formula | C₂₀H₂₁NO₄ |
| Molecular Weight | 339.39 g/mol |
| Beilstein Registry Number | 2177443 |
| EC Number | 272-515-0 |
| MDL Number | MFCD00037124 |
| PubChem Substance ID | 57651055 |
| Optical Activity | [α]²⁰/D -17 ± 1°; c = 1% in DMF |
| Form | Solid |
| Melting Point | 143–147 °C |
| Assay | ≥98.0% by HPLC |
| Storage Temperature | 2–8 °C |
| Functional Groups | Fmoc, amine, carboxylic acid |
Applications
Fmoc-Val-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of valine residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Enzyme-substrate and inhibitor studies
- Protein engineering and structural biology research
- Proteomics and biochemical research
- Bioconjugation and functionalized peptide synthesis
- Studies involving hydrophobic peptide regions and protein stability
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 47638-50G-F | 50 g |
| 47638-250G-F | 250 g |
Storage & Handling
Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture, light, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
No resources are currently available for this product.
Fmoc-Val-OH, also known as Fmoc-L-Valine, is a high-purity, N-protected amino acid derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group, allowing selective deprotection and controlled stepwise peptide elongation.
Valine is a branched-chain hydrophobic amino acid that contributes to protein folding, peptide stability, hydrophobic interactions, and secondary structure formation. Fmoc-Val-OH is therefore an important building block for custom peptide synthesis, pharmaceutical research, drug discovery, proteomics, enzyme-substrate studies, protein engineering, and bioconjugation applications.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| Valine Building Block | Enables incorporation of valine residues into synthetic peptides |
| Hydrophobic Amino Acid | Supports peptide folding, protein stability, and hydrophobic interactions |
| SPPS Compatible | Suitable for solid-phase peptide synthesis and peptide modification |
| Research Applications | Ideal for peptide chemistry, pharmaceutical research, proteomics, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Val-OH, ≥98.0% HPLC |
| Synonym | Fmoc-L-Valine |
| CAS Number | 68858-20-8 |
| Empirical Formula | C₂₀H₂₁NO₄ |
| Molecular Weight | 339.39 g/mol |
| Beilstein Registry Number | 2177443 |
| EC Number | 272-515-0 |
| MDL Number | MFCD00037124 |
| PubChem Substance ID | 57651055 |
| Optical Activity | [α]²⁰/D -17 ± 1°; c = 1% in DMF |
| Form | Solid |
| Melting Point | 143–147 °C |
| Assay | ≥98.0% by HPLC |
| Storage Temperature | 2–8 °C |
| Functional Groups | Fmoc, amine, carboxylic acid |
Applications
Fmoc-Val-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of valine residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Enzyme-substrate and inhibitor studies
- Protein engineering and structural biology research
- Proteomics and biochemical research
- Bioconjugation and functionalized peptide synthesis
- Studies involving hydrophobic peptide regions and protein stability
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 47638-50G-F | 50 g |
| 47638-250G-F | 250 g |
Storage & Handling
Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture, light, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
No resources are currently available for this product.
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Specifications
| Pack Size | 250g, 50g |