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Fmoc-Arg(Pbf)-OH is a high-purity, selectively protected arginine derivative designed for Fmoc-based solid-phase peptide synthesis (SPPS). It contains an Fmoc-protected N-terminal amine and a Pbf-protected guanidino side chain, allowing controlled peptide chain elongation and selective side-chain deprotection during final cleavage.
This reagent is widely used in custom peptide synthesis, pharmaceutical research, proteomics, drug discovery, protein engineering, and bioorganic chemistry. Its high purity and stable protecting-group chemistry make it suitable for efficient incorporation of arginine residues into synthetic peptides.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis |
| Dual Protection | Fmoc protection on the α-amino group and Pbf protection on the arginine side chain |
| SPPS Compatible | Suitable for Fmoc-based solid-phase peptide synthesis workflows |
| Selective Deprotection | Pbf group is removable under acidic cleavage conditions, commonly using TFA |
| Research Grade | Ideal for peptide chemistry, drug discovery, proteomics, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Arg(Pbf)-OH, ≥98.0% HPLC |
| CAS Number | 154445-77-9 |
| Empirical Formula | C₃₄H₄₀N₄O₇S |
| Molecular Weight | 648.77 g/mol |
| Beilstein Registry Number | 8302671 |
| MDL Number | MFCD00235804 |
| PubChem Substance ID | 57650929 |
| Optical Activity | [α]/D -5.5 ± 1.0°; c = 1 in DMF |
| Form | Powder or crystals |
| Assay | ≥98.0% by HPLC |
| Storage Temperature | -20 °C |
| Functional Groups | Fmoc, amine, guanidino, carboxylic acid |
Applications
Fmoc-Arg(Pbf)-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of arginine residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based drug discovery and therapeutic research
- Enzyme-substrate and inhibitor studies
- Protein engineering and structural biology research
- Bioorganic chemistry and peptidomimetic synthesis
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 47349-5G | 5 g |
| 47349-25G | 25 g |
| 47349-100G | 100 g |
| 47349-1KG | 1 kg |
Storage & Handling
Store at -20 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and repeated freeze-thaw cycles. Handle only in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Specification: Fmoc-Arg(Pbf)-OH
Fmoc-Arg(Pbf)-OH is a high-purity, selectively protected arginine derivative designed for Fmoc-based solid-phase peptide synthesis (SPPS). It contains an Fmoc-protected N-terminal amine and a Pbf-protected guanidino side chain, allowing controlled peptide chain elongation and selective side-chain deprotection during final cleavage.
This reagent is widely used in custom peptide synthesis, pharmaceutical research, proteomics, drug discovery, protein engineering, and bioorganic chemistry. Its high purity and stable protecting-group chemistry make it suitable for efficient incorporation of arginine residues into synthetic peptides.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis |
| Dual Protection | Fmoc protection on the α-amino group and Pbf protection on the arginine side chain |
| SPPS Compatible | Suitable for Fmoc-based solid-phase peptide synthesis workflows |
| Selective Deprotection | Pbf group is removable under acidic cleavage conditions, commonly using TFA |
| Research Grade | Ideal for peptide chemistry, drug discovery, proteomics, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Arg(Pbf)-OH, ≥98.0% HPLC |
| CAS Number | 154445-77-9 |
| Empirical Formula | C₃₄H₄₀N₄O₇S |
| Molecular Weight | 648.77 g/mol |
| Beilstein Registry Number | 8302671 |
| MDL Number | MFCD00235804 |
| PubChem Substance ID | 57650929 |
| Optical Activity | [α]/D -5.5 ± 1.0°; c = 1 in DMF |
| Form | Powder or crystals |
| Assay | ≥98.0% by HPLC |
| Storage Temperature | -20 °C |
| Functional Groups | Fmoc, amine, guanidino, carboxylic acid |
Applications
Fmoc-Arg(Pbf)-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of arginine residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based drug discovery and therapeutic research
- Enzyme-substrate and inhibitor studies
- Protein engineering and structural biology research
- Bioorganic chemistry and peptidomimetic synthesis
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 47349-5G | 5 g |
| 47349-25G | 25 g |
| 47349-100G | 100 g |
| 47349-1KG | 1 kg |
Storage & Handling
Store at -20 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and repeated freeze-thaw cycles. Handle only in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Specification: Fmoc-Arg(Pbf)-OH
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Specifications
| Pack Size | 1kg, 100g, 5g, 25g |