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Fmoc-Ser(tBu)-OH, also known as Fmoc-protected serine tert-butyl ether, is a high-purity, selectively protected serine derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group and a tert-butyl-protected hydroxyl side chain, enabling controlled peptide elongation while preventing unwanted side reactions involving the serine hydroxyl group.
This reagent is widely used in custom peptide synthesis, pharmaceutical research, proteomics, drug discovery, protein engineering, synthetic biology, and bioconjugation chemistry. Its protected structure supports efficient incorporation of serine residues into linear, cyclic, and modified peptides.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| tBu Side-Chain Protection | Protects the serine hydroxyl group during peptide elongation |
| SPPS Compatible | Suitable for solid-phase peptide synthesis and peptide modification |
| Reduced Side Reactions | Helps prevent unwanted reactions involving the hydroxyl side chain |
| Versatile Research Use | Suitable for peptide chemistry, drug discovery, protein engineering, and bioconjugation |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Ser(tBu)-OH, ≥98.0% HPLC |
| CAS Number | 71989-33-8 |
| Empirical Formula | C₂₂H₂₅NO₅ |
| Molecular Weight | 383.44 g/mol |
| Beilstein Registry Number | 3632013 |
| EC Number | 276-260-6 |
| MDL Number | MFCD00037127 |
| PubChem Substance ID | 57651041 |
| Optical Activity | [α]²⁰/D +25.5 ± 1°; c = 1% in ethyl acetate |
| Form | Powder |
| Assay | ≥98.0% by HPLC |
| Storage Temperature | 2–8 °C |
| Functional Group | Fmoc |
| Solubility | Soluble in organic solvents; insoluble in water |
Applications
Fmoc-Ser(tBu)-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of serine residues into synthetic peptides
- Linear and cyclic peptide synthesis
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Protein engineering and proteomics research
- Bioconjugation and bioactive molecule design
- Synthetic biology and bioorganic chemistry workflows
- Synthesis of complex peptides and peptide fragments
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 47619-10G-F | 10 g |
| 47619-25G-F | 25 g |
| 47619-100G-F | 100 g |
Storage & Handling
Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture, oxidizing agents, and direct sunlight. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
No resources are currently available for this product.
Fmoc-Ser(tBu)-OH, also known as Fmoc-protected serine tert-butyl ether, is a high-purity, selectively protected serine derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group and a tert-butyl-protected hydroxyl side chain, enabling controlled peptide elongation while preventing unwanted side reactions involving the serine hydroxyl group.
This reagent is widely used in custom peptide synthesis, pharmaceutical research, proteomics, drug discovery, protein engineering, synthetic biology, and bioconjugation chemistry. Its protected structure supports efficient incorporation of serine residues into linear, cyclic, and modified peptides.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| tBu Side-Chain Protection | Protects the serine hydroxyl group during peptide elongation |
| SPPS Compatible | Suitable for solid-phase peptide synthesis and peptide modification |
| Reduced Side Reactions | Helps prevent unwanted reactions involving the hydroxyl side chain |
| Versatile Research Use | Suitable for peptide chemistry, drug discovery, protein engineering, and bioconjugation |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Ser(tBu)-OH, ≥98.0% HPLC |
| CAS Number | 71989-33-8 |
| Empirical Formula | C₂₂H₂₅NO₅ |
| Molecular Weight | 383.44 g/mol |
| Beilstein Registry Number | 3632013 |
| EC Number | 276-260-6 |
| MDL Number | MFCD00037127 |
| PubChem Substance ID | 57651041 |
| Optical Activity | [α]²⁰/D +25.5 ± 1°; c = 1% in ethyl acetate |
| Form | Powder |
| Assay | ≥98.0% by HPLC |
| Storage Temperature | 2–8 °C |
| Functional Group | Fmoc |
| Solubility | Soluble in organic solvents; insoluble in water |
Applications
Fmoc-Ser(tBu)-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of serine residues into synthetic peptides
- Linear and cyclic peptide synthesis
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Protein engineering and proteomics research
- Bioconjugation and bioactive molecule design
- Synthetic biology and bioorganic chemistry workflows
- Synthesis of complex peptides and peptide fragments
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 47619-10G-F | 10 g |
| 47619-25G-F | 25 g |
| 47619-100G-F | 100 g |
Storage & Handling
Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture, oxidizing agents, and direct sunlight. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
No resources are currently available for this product.
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Specifications
| Pack Size | 100g, 10g, 25g |