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Sigma-Aldrich™ ProClin™ 300 Preservative (CMIT/MIT 3%)
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High-Performance Microstatic Preservative for IVD Manufacturing
Specifications:
| Application | Life Science Applications | ||
| Storage Temperature | Ambient | ||
| Product Type | Enzymes and Substrates, antimicrobials | Forms | Liquid |
| Product Brand | Sigma-Aldrich | ||
| Product Grade | Laboratory grade | ||
The Sigma-Aldrich™ ProClin™ 300 is a highly effective microstatic preservative system specifically developed for use in in vitro diagnostic (IVD) manufacturing. Formulated with 3% CMIT/MIT (chloromethylisothiazolinone/methylisothiazolinone), ProClin™ 300 provides rapid and long-lasting protection against microbial contamination in aqueous formulations.
Its advanced mechanism of action targets multiple cellular pathways, enabling broad-spectrum antimicrobial efficacy while minimizing the risk of microbial resistance. ProClin™ 300 is widely used in the stabilization of diagnostic reagents, buffers, calibrators, and control materials.
Key Features
-
Broad-Spectrum Microstatic Activity
Rapidly inhibits bacterial, fungal, and yeast growth. -
Dual-Active CMIT/MIT System (3%)
Ensures effective microbial control through multiple biochemical pathways. -
Fast-Acting & Long-Lasting Protection
Immediate antimicrobial action upon contact with microorganisms. -
Wide pH Compatibility (2.5 – 8.5)
Suitable for diverse IVD formulations. -
Excellent Stability in Aqueous Systems
Fully water-soluble and compatible with glycol-based matrices. -
Low Resistance Development
Multi-target mechanism reduces risk of microbial adaptation. -
Long Shelf Life (3 Years)
Ensures stability for extended storage of IVD components.
Applications
- IVD Reagent Manufacturing
- Diagnostic Buffers & Solutions Preservation
- Calibrators and Control Materials Stabilization
- ELISA, PCR, and Immunoassay Reagents
- Laboratory Reagent Preservation Systems
- Biotechnology and Analytical Reagent Formulations
Technical Specifications
| Parameter | Specification |
|---|---|
| Product Name | ProClin™ 300 |
| Composition | CMIT/MIT (3%) |
| Form | Liquid |
| Color | Colorless to light yellow |
| Matrix | Modified glycol |
| Density | 1.03 g/cm³ |
| pH (100 g/L) | 4.1 |
| Operating pH Range | 2.5 – 8.5 |
| Operating Temperature | <45 °C |
| Boiling Point | 189 °C |
| Melting Point | -40 °C |
| Solubility | Water: Soluble |
| Shelf Life | 3 years |
| Stabilizer | Alkyl carboxylate |
Packaging & Ordering Information
| Product Number | Pack Size | Description |
|---|---|---|
| 48912-U | 50 mL | ProClin™ 300 (CMIT/MIT 3%) |
| 48914-U | 400 mL | ProClin™ 300 (CMIT/MIT 3%) |
| 48915-U | 2.0 L | ProClin™ 300 (CMIT/MIT 3%) |
| 46878-U | 3.6 L | ProClin™ 300 (CMIT/MIT 3%) |
| 48918-U | 18 L | ProClin™ 300 (CMIT/MIT 3%) |
| 49376-U | 3 × 5 mL | Method Development Kit (3 lots) |
Related Variants (Product Family)
| Product | Composition | Application |
|---|---|---|
| ProClin™ 150 | CMIT/MIT 1.5% | Lower concentration preservation |
| ProClin™ 300 | CMIT/MIT 3% | Standard IVD preservation |
| ProClin™ 950 | MIT 9.5% | High-strength antimicrobial system |
Mechanism of Action
ProClin™ preservatives exhibit rapid microstatic activity by:
- Penetrating microbial cell membranes
- Inhibiting key enzymes involved in cellular respiration
- Disrupting metabolic pathways
This multi-site mode of action significantly reduces the likelihood of resistance development, ensuring sustained antimicrobial performance over time.
Safety & Handling
- Handle with appropriate PPE (gloves, lab coat, eye protection)
- Avoid direct contact with skin and eyes
- Use in well-ventilated laboratory conditions
- Refer to Safety Data Sheet (SDS) before use
Regulatory & Compliance Notice
- Intended for IVD manufacturing use only
-
Not classified as a biocide under global biocide regulations including:
- US EPA (FIFRA)
- EU Biocidal Products Regulation (BPR)
- PMRA (Canada)
- K-BPR (Korea)
- Pack Size: 50 mL 400 mL 3 × 5 mL 2.0 L 3.6 L 18.0 L