Sigma-Aldrich Thionyl chloride for synthesis

Sigma-Aldrich Thionyl Chloride is a high-purity synthesis-grade chlorinating agent widely used in organic chemistry to convert alcohols and carboxylic acids into alkyl and acyl chlorides. With ≥99.0% assay purity (argentometric), it is ideal for reliable and consistent results in demanding laboratory and industrial synthesis protocols.

Key Features

• High Purity – Assay ≥ 99.0% (argentometric), suitable for fine chemical and pharmaceutical synthesis
• Versatile Chlorinating Agent – Ideal for converting hydroxyl and carboxyl groups to chlorinated derivatives
• Broad Synthetic Utility – Enables formation of sulfinyl-based compounds and cyclic structures
• Synthesis Grade – Suitable for organic transformations, intermediates, and reagent-level applications
• Available in Multiple Pack Sizes – 100 mL, 500 mL, 1 L, 2.5 L

Chemical and Physical Properties

Applications

Thionyl chloride is widely used in chlorination reactions and synthetic organic chemistry, including:

• Synthesis of acyl and alkyl chlorides from carboxylic acids and alcohols
• Formation of 4-(sulfinylamino)-1,2,4-triazoles, isothiazolopyrimidines, and 1,2,6-triazine S-oxides
• Cyclization reactions leading to dioxathianes and cyclic sulfites
• Synthesis of microporous organic polymers via aldol self-condensation
• Intermediate in pharmaceuticals and fine chemicals

Safety and Handling

• Hazard Classification: Corrosive, toxic if inhaled or swallowed
• Precautions: Handle in a well-ventilated fume hood using appropriate PPE
• Storage: Store in tightly sealed containers under dry, temperature-controlled conditions

Ordering Information

Sigma-Aldrich Thionyl Chloride offers synthesis-grade reliability for a broad spectrum of chlorination and condensation reactions in organic chemistry. Its high purity, versatility, and reactivity make it a preferred reagent for research, development, and production in chemical laboratories and industries.