Sigma-Aldrich (+)-Sodium L-ascorbate crystalline, ≥98%

High-Purity, Water-Soluble Antioxidant and Reducing Agent for Biochemical and Cell Culture Applications

(+)-Sodium L-ascorbate (CAS No. 134-03-2) is a crystalline, water-soluble sodium salt of L-ascorbic acid (Vitamin C) with a purity of ≥98%, making it suitable for a wide range of biochemical, physiological, and cell culture applications. As a potent reducing agent and antioxidant, sodium L-ascorbate protects biological systems from oxidative damage and supports enzymatic functions such as collagen synthesis, neurotransmitter production, and reactive oxygen species (ROS) detoxification.

Manufactured to Sigma-Aldrich’s Quality Level 300, this synthetic-grade compound is trusted for its consistency and is suitable for use in HPLC, tissue preservation, and primary cell culture systems, especially where control of oxidative stress is critical.

Key Features & Benefits

• High Purity (≥98%)
  Suitable for demanding biochemical and physiological studies requiring high-grade reducing agents.
• Crystalline Form
  Ensures easy handling, precise measurement, and stability under proper storage conditions.
• Water-Soluble Sodium Salt
  Readily dissolves in aqueous solutions; ideal for cell culture, enzyme assays, and in vivo models.
• Strong Antioxidant Properties
  Neutralizes hydrogen peroxide and free radicals; protects cells from oxidative damage.
• Biologically Active Form
  Supports synthesis of catecholamines and adrenal steroids; promotes collagen formation in smooth muscle cell culture.

Applications

• Cell Culture & Neurobiology
  • Used in slicing solutions and intracellular solutions for brain slice preparations and Ca²⁺ imaging
  • Antioxidant supplement in neuronal and smooth muscle cell cultures
• Biochemical Assays
  • Reduces metal ions and stabilizes redox-sensitive components
  • Acts as a primary substrate for ROS detoxification systems
• Tissue & Organ Preservation
  • Added to artificial cerebrospinal fluid (aCSF) and preservation buffers to maintain tissue viability
• Collagen Production Studies
  • Enhances collagen synthesis in arterial smooth muscle cells

Specifications Table

Available Pack Sizes & SKUs

Biochemical/Physiological Actions

• Detoxifies hydrogen peroxide and other reactive oxygen species
• Supports synthesis of catecholamines, adrenal steroids, and collagen
• Recycled within biological systems as part of redox homeostasis
• Used in vitamin C regeneration studies and metabolic pathway research

Sigma-Aldrich (+)-Sodium L-ascorbate, crystalline, ≥98% is a versatile and reliable antioxidant widely used in neurobiology, redox biology, and tissue culture. Its high purity and excellent solubility make it suitable for a variety of academic, clinical, and pharmaceutical applications requiring precise oxidative stress management and metabolic support.