RiboGrip® Glycerol-Free RNase Inhibitor (220 U/µl)

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Specifications:

Application	Reverse Transcription
Storage Temperature	-20°C
Product Type	PCR Reagent	Forms	Liquid
Product Brand	Solis Biodyne
Product Grade	Molecular Biology

Overview
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The RiboGrip® Glycerol-Free RNase Inhibitor is a novel, in silico–engineered protein-based inhibitor designed to protect RNA from degradation by contaminating ribonucleases. This high-concentration (220 U/µl), glycerol-free formulation is fully compatible with lyophilization and air-drying, making it ideal for developing portable or stabilized RNA workflows.

Powered by Solis BioDyne’s patented Stability TAG™ technology, RiboGrip® offers exceptional heat stability, retaining full activity for 1 hour at 60°C. It efficiently inactivates RNase A, RNase B, and RNase C, ensuring robust RNA protection across diverse applications including cDNA synthesis, RT-qPCR, RT-LAMP, RNA sequencing, and in vitro transcription.

Key Features & Benefits

Glycerol-Free Formulation – Compatible with lyophilization and air-drying workflows.
Exceptional Thermal Stability – Stable up to 60°C; retains activity after prolonged exposure.
Novel Protein Design – In silico–engineered RNase inhibitor with Stability TAG™ technology.
RNA Integrity Protection – Effective at low DTT concentrations, ensuring RNA remains intact.
High Concentration (220 U/µl) – Allows flexible and efficient use across molecular assays.
Proven Performance – Clients report excellent functionality following lyophilization.
Broad Assay Compatibility – Suitable for RNA workflows, including Illumina single-cell sequencing protocols.

Applications

First-strand cDNA synthesis
RT-PCR and RT-qPCR
RT-LAMP isothermal amplification
In vitro transcription and translation
RNA isolation and purification
RNA sequencing workflows
Lyophilized or air-dried diagnostic assays

Product Specifications

Attribute	Detail
Concentration	220 U/µl
Specificity	RNase A, RNase B, RNase C
Origin	Recombinant mammalian chimeric protein
Source	Purified from E. coli overexpression system
Molecular Weight	47 kDa (monomer)
Unit Definition	1 U inhibits 5 ng RNase A by 50%
Recommended Use	0.5–2.5 U/µl final reaction concentration
Storage Buffer	25 mM Tris-HCl (pH 7.5), 100 mM KCl, 0.1 mM EDTA, 5 mM DTT, stabilizers
Stability	Stable for 1 month at RT; routine storage at –20°C
Shipping	Room temperature

Ordering Information

Catalog Number	Size	Reaction Capacity
06-29-2000U	2000 U	100 rxn
06-29-4000U	4000 U	200 rxn
06-29-010kU	10,000 U	500 rxn
06-29-050kU	50,000 U	5000 rxn

The RiboGrip® Glycerol-Free RNase Inhibitor (220 U/µl) offers next-generation RNA protection with compatibility for lyophilization, high-temperature workflows, and air-drying. With its Stability TAG™ technology, high concentration, and proven effectiveness across molecular biology applications, it is the ideal solution for RNA research, sequencing, and diagnostic assay development where RNA integrity is critical.