Remel™ Coagulase Plasma

Detect coagulase enzyme in staphylococci with Thermo Scientific™ Remel™ Coagulase Plasma. The enzyme coagulase acts on a constituent of rabbit plasma to produce a thrombin-like substance which activates fibrinogen to form fibrin clot. In 1940, Fairbrother and Chapman et al. reported pathogenic staphylococci can be identified based on the ability to coagulate plasma.1,2 Chapman found rabbit plasma to be superior to other types of plasma in terms of clotting activity.3 Bayliss and Hall recommended replacing the citrate anticoagulant with EDTA to avoid false-positive clots.

Detect coagulase enzyme in staphylococci with Coagulase Plasma. The enzyme coagulase acts on a constituent of rabbit plasma (coagulase reacting factor) to produce a thrombin-like substance. This substance activates fibrinogen to form fibrin which results in the formation of a fibrin clot. Coagulase is present in two forms: bound coagulase, or clumping factor, remains attached to the cell wall of the organism; free coagulase is an extracellular enzyme produced when the organism is cultured in broth. Bound coagulase is detected in the slide test, while the tube test will detect bound and free coagulase.

• Rapid: Results within 10 seconds.
• Accurate results: Presence of EDTA as an anticoagulant helps avoiding false-positive clots

Lyophilized Coagulase plasma is rehydrated before use for this test.