Remel™ Shigella dysenteriae Polyvalent (1-10) Agglutinating Sera

The Remel™ Shigella dysenteriae Polyvalent (1-10) Agglutinating Sera is a serological diagnostic tool designed for the presumptive identification of Shigella dysenteriae types 1 to 10. It provides visible agglutination results using slide agglutination tests, aiding in epidemiological and clinical diagnostics.

Key Features

1. Ready-to-Use Reagents:
   • Pre-formulated liquid sera, supplied in 2 mL dropper vials, preserved with 0.5% phenol for immediate use.
2. Rapid Results:
   • Detects Shigella dysenteriae types 1 to 10 through visible agglutination, offering results within minutes.
3. High Specificity:
   • Identifies Shigella dysenteriae types while differentiating from non-motile serotypes of E. coli (Alkalescens‑Dispar group).
   • Additional differentiation serum available (R30164301).
4. Ease of Interpretation:
   • Positive results show visible agglutination with S. dysenteriae types 1 to 10.
   • Negative controls ensure clear and reliable outcomes.
5. Complementary Testing:
   • Designed for serological identification; full organism identification requires biochemical testing.

Applications

1. Clinical Diagnostics:
   • Supports the identification of Shigella dysenteriae in patients suspected of having bacterial dysentery.
   • Aids in determining appropriate treatment options.
2. Epidemiology:
   • Assists in outbreak investigations by identifying Shigella dysenteriae serotypes.
   • Tracks transmission and prevalence of Shigella in populations.
3. Research:
   • Facilitates studies on the classification and serotyping of Shigella dysenteriae.
   • Enhances understanding of the antigenic properties of Shigella strains.

Specifications

Intended Use

• For qualitative slide agglutination testing of Shigella dysenteriae isolates grown on agar.
• Assists in the presumptive serological identification of Shigella species as part of a diagnostic workflow.
• Not automated; for professional use only.

Benefits

1. Fast and Reliable:
   • Provides visible agglutination results quickly, aiding in rapid diagnostic workflows.
2. Specific Serotyping:
   • Covers Shigella dysenteriae types 1–10, ensuring broad applicability in clinical and research settings.
3. Cost-Effective:
   • Minimizes delays in serological testing, supporting timely patient management and outbreak investigations.
4. Versatile Testing:
   • Can be used for clinical, epidemiological, and research purposes.

How It Works

1. Sample Preparation:
   • Grow Shigella dysenteriae isolates on agar.
2. Agglutination Testing:
   • Place a drop of the test serum on a clean glass slide.
   • Add a small amount of bacterial culture and mix.
3. Result Interpretation:
   • Positive Result: Visible clumping/agglutination indicates the presence of homologous S. dysenteriae antigens.
   • Negative Result: No agglutination indicates absence of homologous antigens.
4. Controls:
   • Use provided controls to verify reagent performance and result validity.

Storage and Handling

• Store at 2°C to 8°C to maintain reagent stability.
• Ensure reagents are used within their specified shelf life.

Additional Information

• Antigenic Differentiation: Distinguishes Shigella dysenteriae from other bacterial species, including non-motile E. coli serotypes.
• Epidemiological Relevance: Helps identify specific Shigella dysenteriae types involved in outbreaks of bacterial dysentery.

The Remel™ Shigella dysenteriae Polyvalent (1-10) Agglutinating Sera is a reliable, easy-to-use diagnostic tool for rapid serotyping of S. dysenteriae. Its precision, speed, and applicability make it a valuable resource for clinical, epidemiological, and research applications.