Liofilchem™ MTS™ Meropenem-vaborbactam M/V 0.016/8-256/8, MIC Test strips

The Liofilchem™ MTS™ Meropenem-vaborbactam MIC Test Strips are innovative tools for determining the Minimum Inhibitory Concentration (MIC) of Meropenem in combination with Vaborbactam. These test strips are indispensable in antimicrobial susceptibility testing (AST) for multidrug-resistant (MDR) Gram-negative pathogens, offering precision and reliability for clinical and research applications.

Key Features

1. Dual Antibiotic Combination:
   • Evaluates the effectiveness of Meropenem, a carbapenem antibiotic, combined with Vaborbactam, a beta-lactamase inhibitor.
2. Wide MIC Range:
   • 0.016/8 to 256/8 µg/mL: Suitable for detecting both highly susceptible and resistant bacterial strains.
3. Precision Gradient Diffusion:
   • Provides accurate MIC values using a continuous antibiotic gradient on the test strip.
4. Effective Resistance Detection:
   • Specifically designed for carbapenem-resistant Enterobacterales (CRE) and beta-lactamase producers such as Klebsiella pneumoniae carbapenemase (KPC).
5. Compliant with CLSI and EUCAST Standards:
   • Ensures reliable and standardized testing results.

Applications

• Clinical Diagnostics:
  • Detect susceptibility of Gram-negative pathogens, including Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp..
  • Guide treatment strategies for infections caused by carbapenem-resistant organisms.
• Pharmaceutical Research:
  • Evaluate the efficacy of Meropenem-vaborbactam combinations in antimicrobial development.
  • Study resistance mechanisms in carbapenemase-producing bacteria.
• Veterinary Microbiology:
  • Monitor antimicrobial resistance in animal pathogens.

Testing Procedure

1. Preparation:
   • Adjust bacterial suspension to 0.5 McFarland standard.
   • Spread suspension uniformly on Mueller-Hinton agar plates.
2. Application:
   • Place the MTS™ Meropenem-vaborbactam strip on the inoculated agar surface using sterile forceps.
3. Incubation:
   • Incubate plates at 35–37°C for 16–20 hours in aerobic conditions.
4. Interpretation:
   • Read the MIC value where the bacterial inhibition zone edge intersects the strip's scale.

Storage and Stability

• Keep strips in a dry, sterile environment to maintain potency.
• Avoid repeated freeze-thaw cycles.

Advantages

1. Accurate Resistance Detection:
   • Sensitive to carbapenemase-producing and beta-lactamase-producing pathogens.
2. Comprehensive Testing Range:
   • Wide MIC range ensures detection of both susceptible and resistant strains.
3. Easy to Use:
   • Simplified workflow for integration into standard laboratory procedures.
4. High Sensitivity and Specificity:
   • Reliable results for even low-level resistance detection.

Technical Specifications Table

Why Choose Liofilchem™ MTS™ Meropenem-vaborbactam?

The Liofilchem™ MTS™ Meropenem-vaborbactam Test Strips provide an unparalleled solution for detecting and studying antimicrobial resistance in multidrug-resistant bacteria. Their precision, ease of use, and compliance with international standards make them essential for laboratories focused on combating antibiotic resistance.