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Liofilchem™ MTS™ Meropenem MRP 0.016-256, MIC Test strips
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Specifications:
| Application | Clinical microbiology |
| Storage Temperature | -20°C |
| Product Type | MIC Strips |
| Product Brand | Liofilchem |
| Product Grade | Microbiology grade |
The Liofilchem™ MTS™ Meropenem MIC Test Strips are a robust tool for determining the Minimum Inhibitory Concentration (MIC) of Meropenem for Gram-negative bacterial pathogens. These strips are vital for detecting carbapenem resistance, supporting antimicrobial susceptibility testing (AST) in clinical, pharmaceutical, and research laboratories.
Key Features
- Broad MIC Range:
- Spanning from 0.016 µg/mL to 256 µg/mL, enabling precise detection of both susceptible and highly resistant bacterial strains.
- High Sensitivity:
- Detects carbapenemase-producing organisms, including multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa.
- Gradient Diffusion Technology:
- Provides an accurate antibiotic gradient for determining MIC values without additional dilution steps.
- Standards Compliant:
- Adheres to CLSI and EUCAST guidelines for antimicrobial susceptibility testing.
- Simple Workflow:
- Easy to use with direct application to inoculated agar plates, minimizing processing time and errors.
Testing Procedure
- Preparation:
- Prepare a bacterial suspension matching 0.5 McFarland standard.
- Spread the suspension evenly on Mueller-Hinton agar plates.
- Application:
- Place the MTS™ Meropenem strip onto the agar surface using sterile forceps.
- Incubation:
- Incubate plates at 35–37°C for 16–20 hours under aerobic conditions.
- Interpretation:
- Determine the MIC value at the point where the bacterial growth inhibition intersects the strip's scale.
Storage and Stability
| Condition | Temperature | Duration |
|---|---|---|
| Long-Term Storage | -20°C | Until expiration date |
| Short-Term Storage | 2–8°C | Up to 2 weeks |
| During Use | Room Temperature | Immediate use only |
Technical Specifications
| Feature | Details |
|---|---|
| Active Component | Meropenem |
| MIC Range | 0.016–256 µg/mL |
| Test Method | Gradient diffusion |
| Compatible Media | Mueller-Hinton agar |
| Incubation Conditions | 35–37°C for 16–20 hours |
| Target Pathogens | Gram-negative bacteria, including carbapenemase producers |
| Shelf Life | As per expiration date on packaging |
| Pack Sizes | 10 or 30 or 100 test strips per pack |
Quality Control Data
| Control Organism | Expected MIC Range |
|---|---|
| Escherichia coli ATCC® 25922 | 0.008–0.06 µg/mL |
| Pseudomonas aeruginosa ATCC® 27853 | 1–4 µg/mL |
| Klebsiella pneumoniae ATCC® 700603 | Resistant MIC (≥8 µg/mL) |
| Staphylococcus aureus ATCC® 29213 | Not applicable (Gram-positive) |
- Positive Controls: Ensure correct detection of susceptible and resistant strains.
- Negative Controls: Rule out false resistance due to environmental contamination or misapplication.
Advantages
| Feature | Benefit |
|---|---|
| Broad MIC Range | Accommodates low- and high-resistance bacterial strains. |
| Ease of Use | Simplified setup reduces laboratory processing time. |
| High Sensitivity | Detects resistance with precision for clinical accuracy. |
| Compliance with Standards | Ensures reproducibility across global testing protocols. |
Comparison of Meropenem MIC Ranges Across Test Strips
| MTS Test Strip | MIC Range (µg/mL) | Recommended Use |
|---|---|---|
| Meropenem MRP 0.016–256 | 0.016–256 | For resistant strains and carbapenemase producers. |
| Meropenem MRP 0.002–32 | 0.002–32 | For low-resistance detection. |
| Meropenem-vaborbactam 0.016/8–256/8 | 0.016/8–256/8 | Beta-lactamase inhibition studies. |
Interpretation of Results
| MIC Value (µg/mL) | Interpretation (Based on CLSI/EUCAST) |
|---|---|
| ≤2 | Susceptible |
| 4 | Intermediate |
| ≥8 | Resistant |
Why Choose Liofilchem™ MTS™ Meropenem MRP 0.016–256?
The Liofilchem™ MTS™ Meropenem MRP Test Strips are highly versatile, allowing precise and efficient detection of susceptibility and resistance in Gram-negative pathogens. Their broad MIC range, ease of use, and compliance with international standards make them an indispensable tool for clinical laboratories, research institutions, and pharmaceutical development.
These strips provide fast, accurate, and reproducible results, essential for guiding effective antimicrobial therapy and monitoring the emergence of resistance.
- Pack Size: 100/pk 10/pk 30/pk