Liofilchem™ MTS™ Flucytosine FC 0.002-32, MIC Test strips

The Liofilchem™ MTS™ Flucytosine MIC Test Strips provide a quantitative, standardized method for determining the minimum inhibitory concentration (MIC) of flucytosine (5-FC) against clinically significant fungi. Each strip incorporates a continuous gradient of flucytosine across the range of 0.002–32 µg/mL, enabling precise antifungal susceptibility testing directly on agar plates.

These strips offer a simple agar-based alternative to broth microdilution methods (CLSI/EUCAST), with proven accuracy and reproducibility.

Key Features

• Antifungal gradient strip for flucytosine (5-FC).
• MIC range: 0.002–32 µg/mL.
• Quantitative results comparable to CLSI/EUCAST broth microdilution.
• User-friendly format for routine laboratory antifungal testing.
• Available in 10, 30, and 100 pack sizes.
• Manufactured by Liofilchem®, ISO-certified for quality and traceability.

Use Cases

1. Clinical Microbiology Laboratories
   • Antifungal susceptibility testing of Candida spp. and Cryptococcus neoformans.
   • Provides MIC data to guide patient therapy in systemic and invasive fungal infections.
2. Hospital Infection Control & Stewardship
   • Detects flucytosine resistance, ensuring appropriate antifungal selection.
   • Supports antifungal stewardship programs and treatment optimization.
3. Epidemiological & Resistance Surveillance
   • Used to monitor resistance trends in Candida and Cryptococcus strains.
   • Generates standardized data for regional or global antifungal surveillance networks.
4. Research & Development
   • Studies of flucytosine activity in combination therapies (e.g., flucytosine + amphotericin B).
   • Benchmarking antifungal potency in experimental antifungal drug development.

Clinical Significance

• Flucytosine (5-FC) is a pyrimidine analog antifungal that interferes with fungal DNA and RNA synthesis.
• It is especially significant in the treatment of:
  • Cryptococcal meningitis (in combination with amphotericin B).
  • Systemic candidiasis and chromoblastomycosis.
• Resistance to flucytosine can emerge quickly if used as monotherapy, making routine susceptibility testing critical.
• MIC determination with MTS™ strips helps ensure clinical efficacy, prevent treatment failure, and guide combination therapy decisions.

Ordering Information

The Liofilchem™ MTS™ Flucytosine (FC) 0.002–32 MIC Test Strips are a reliable, accurate, and standardized tool for antifungal susceptibility testing. With their broad MIC range and reproducibility, they are particularly valuable in detecting Cryptococcus and Candida resistance to flucytosine, supporting clinical decision-making, antifungal stewardship, and resistance surveillance. These strips remain indispensable in both routine clinical microbiology labs and research settings.