Liofilchem™ MTS™ Caspofungin CAS 0.002-32, MIC Test strips

The Liofilchem™ MTS™ Caspofungin MIC Test Strips are quantitative gradient diffusion assays designed for determining the minimum inhibitory concentration (MIC) of caspofungin (CAS) against clinically important fungi. Each strip contains a continuous antifungal gradient from 0.002 to 32 µg/mL, providing reliable and accurate MIC results.

These strips offer an agar-based, easy-to-use alternative to reference CLSI/EUCAST broth microdilution methods, ensuring high reproducibility in clinical and research laboratories.

Key Features

• Gradient diffusion strip for caspofungin (CAS).
• Wide MIC range: 0.002–32 µg/mL.
• Accurate and reproducible antifungal susceptibility testing.
• Agar-based format, simpler than broth microdilution.
• Conforms with CLSI/EUCAST susceptibility testing guidelines.
• Available in packs of 10, 30, and 100 strips.

Use Cases

1. Clinical Microbiology Laboratories
   • Testing susceptibility of Candida spp. (including azole-resistant strains).
   • Used for guiding antifungal therapy in invasive candidiasis and candidemia.
2. Antifungal Stewardship Programs
   • Detects echinocandin resistance, ensuring correct therapeutic choices.
   • Supports optimized antifungal prescribing in hospitals.
3. Epidemiology & Resistance Surveillance
   • Monitoring resistance trends in Candida and emerging fungi.
   • Data for national and global antifungal resistance databases.
4. Research & Development
   • Comparative testing with other echinocandins (e.g., micafungin, anidulafungin).
   • Evaluating resistance mechanisms in Candida and Aspergillus spp.

Clinical Significance

• Caspofungin is an echinocandin antifungal that inhibits β-(1,3)-D-glucan synthesis, an essential component of the fungal cell wall.
• It is widely used in the treatment of:
  • Invasive candidiasis
  • Candidemia
  • Refractory Aspergillus infections (in salvage therapy)
• Resistance to echinocandins has been increasing, especially in Candida glabrata and Candida auris, highlighting the need for routine MIC testing.
• The use of Liofilchem™ MTS™ Caspofungin strips ensures:
  • Reliable identification of resistant strains.
  • Improved antifungal stewardship and treatment outcomes.
  • Strong support for resistance surveillance and clinical research.

Ordering Information

The Liofilchem™ MTS™ Caspofungin (CAS) 0.002–32 MIC Test Strips provide a robust, standardized, and easy-to-use method for antifungal susceptibility testing. With their wide MIC range, reproducibility, and clinical significance, these strips are vital for detecting echinocandin resistance, guiding patient treatment, and supporting antifungal stewardship. They are indispensable in clinical microbiology labs, surveillance programs, and antifungal research.