Liofilchem™ MTS™ Amoxicillin-clavulanic acid AMC 0.016/2-256/2, MIC Test strips

The Liofilchem™ MTS™ Amoxicillin-Clavulanic Acid (AMC) MIC Test Strips are designed to determine the Minimum Inhibitory Concentration (MIC) of amoxicillin-clavulanic acid against various bacterial pathogens. These strips are essential tools in antimicrobial susceptibility testing, particularly for detecting resistance mechanisms such as beta-lactamase production in Gram-positive and Gram-negative bacteria.

Key Features

1. Dual-Drug Gradient

• The strip contains a two-drug gradient:
  • Amoxicillin: A broad-spectrum beta-lactam antibiotic.
  • Clavulanic acid: A beta-lactamase inhibitor that protects amoxicillin from enzymatic degradation.
• The gradient ranges from 0.016/2 to 256/2 µg/mL for precise MIC determination.

2. Wide Application Range

• Suitable for testing a variety of organisms, including:
  • Beta-lactamase-producing pathogens.
  • Extended-Spectrum Beta-Lactamase (ESBL) and AmpC producers.
  • Multi-drug resistant (MDR) bacteria.

3. High Precision

• Provides accurate and reproducible MIC values for guiding antimicrobial therapy.

4. Easy-to-Use

• Simple gradient diffusion method:
  • Place the strip on an inoculated agar plate.
  • Incubate at the recommended temperature and duration.
  • Read the MIC where the bacterial growth inhibition intersects the strip.

5. Compliance

• Follows international standards such as CLSI and EUCAST for antimicrobial susceptibility testing.

Specifications

Applications

1. Clinical Diagnostics:
   • Identifies the susceptibility of Gram-positive and Gram-negative bacteria to amoxicillin-clavulanic acid.
   • Detects resistance mechanisms such as beta-lactamase activity.
2. Antimicrobial Resistance Monitoring:
   • Aids in tracking the prevalence of resistant bacterial strains.
3. Hospital Infection Control:
   • Provides critical data to guide effective antimicrobial therapy in healthcare settings.
4. Research and Development:
   • Facilitates the study of bacterial resistance mechanisms and new therapeutic options.

Advantages

1. Accurate Resistance Detection:
   • Ideal for identifying beta-lactamase-producing organisms, including ESBL and AmpC strains.
2. Precise and Reliable:
   • Offers reproducible MIC values essential for determining appropriate antibiotic regimens.
3. Convenience and Simplicity:
   • Easy-to-use format reduces laboratory workload and training requirements.
4. Broad Applicability:
   • Suitable for clinical, food safety, and environmental microbiology laboratories.

How It Works

1. Prepare a bacterial suspension and inoculate a Mueller-Hinton agar plate.
2. Place the MTS™ AMC test strip on the agar surface.
3. Incubate under recommended conditions (typically 16–20 hours at 35–37°C).
4. Observe the growth inhibition zone. The MIC is the value where bacterial growth inhibition intersects the strip.

Why Choose Liofilchem™ MTS™ AMC Test Strips?

The Liofilchem™ MTS™ Amoxicillin-Clavulanic Acid Test Strips offer a dependable, efficient, and accurate method to determine the MIC for amoxicillin-clavulanic acid. With their wide range, ease of use, and compliance with global standards, they are indispensable tools for clinical laboratories and research institutions aiming to combat antimicrobial resistance.