Amino-functionalized silica nanoparticles for conjugation chemistry, nanobiotechnology, drug delivery, coatings, and nanocomposite engineering

Sigma-Aldrich silica nanoparticles (<30 nm, DLS) functionalized with triethoxylpropylaminosilane (NH₂-functionalized) provide a versatile, highly reactive nanomaterial designed for biological, chemical, and materials science applications. Supplied as a stable aqueous dispersion, these nanoparticles are engineered for optimal surface activity, bioconjugation, and compatibility with aqueous processing.

The surface amine functionality offers a powerful synthetic handle for coupling reactions (e.g., EDC/NHS, glutaraldehyde crosslinking, covalent ligand conjugation), enabling custom surface modification for gene delivery, biomolecule immobilization, drug loading, and hybrid nanocomposite formation.

These nanoparticles exhibit excellent stability, uniformity, and dispersibility, making them ideal for advanced R&D in biomedical engineering, catalysis, functional coatings, smart materials, and biointerfaces.

Key Features & Benefits

Amino-Functionalized Nanoparticles

• Surface modified with triethoxylpropylaminosilane
• Reactive NH₂ groups for chemical conjugation
• Enables covalent attachment of peptides, proteins, nucleic acids, dyes, drugs, polymers, ligands

Ultrafine Silica Nanoparticles (<30 nm)

• Dynamic Light Scattering (DLS) size <30 nm
• High surface area for efficient binding or loading
• Excellent colloidal stability in aqueous media

Aqueous Dispersion

• Delivered as a ready-to-use water-based dispersion
• No organic solvents required
• High compatibility with biological and nanomaterial systems

High Stability & Controlled Quality

• Shelf life: 1 year
• Density: 1.158 g/mL at 25 °C
• Highly uniform particle distribution
• Produced under controlled nanomaterial standards

Chemical & Regulatory Information

Applications

1. Bioconjugation & Biointerfaces

• Covalent immobilization of proteins, antibodies, peptides
• DNA/RNA attachment for diagnostic or delivery systems
• Fluorophore or dye conjugation for imaging

2. Gene & Drug Delivery

• Carrier systems for in vivo or in vitro gene transfer
• Nanocarrier for small-molecule or macromolecule drugs
• Controlled-release formulations

3. Tissue & Bone Engineering

• Bioactive scaffold reinforcement
• Osteoconductive nanofillers for bone regeneration
• ECM-mimetic nanocomposite development

4. Nanocomposites & Advanced Materials

• Polymer–silica hybrid materials
• Mechanical reinforcement of resins
• High-performance coatings and adhesives
• Electrically/optically active nanocomposites

5. Biofilm Engineering & Surface Modification

• Tuning cellular adhesion and bacterial biofilm formation
• Creating functional biomaterial surfaces
• Smart responsive surface coatings

Ordering Information

Sigma-Aldrich amine-functionalized silica nanoparticles (<30 nm, aqueous dispersion) offer a highly reactive, versatile platform for bioconjugation, drug delivery, nanocomposites, tissue engineering, and functional coatings. With controlled surface chemistry, excellent colloidal stability, and broad compatibility with biological and materials applications, these nanoparticles are an essential tool for advanced nanotechnology and bioengineering research.