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Sigma-Aldrich™ Novabiochem® Fmoc-Trp-OH, ≥98.0% (HPLC)
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Specifications:
| Application | Protein Biology, Peptide Synthesis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Amino Acid & Biochemicals | Forms | Powder |
| Product Brand | Sigma-Aldrich | ||
| Product Grade | HPLC Grade | Formula | C₂₆H₂₂N₂O₄ |
Fmoc-Trp-OH, also known as Fmoc-protected L-tryptophan, is a high-purity, N-protected amino acid derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group and an unprotected indole side chain, making it a useful tryptophan building block for peptide synthesis workflows where Boc side-chain protection is not required.
Tryptophan is an aromatic amino acid that plays an important role in protein folding, hydrophobic interactions, enzyme recognition, ligand binding, and fluorescence-based studies. Fmoc-Trp-OH is therefore widely used in custom peptide synthesis, pharmaceutical research, proteomics, structural biology, protein engineering, bioorganic chemistry, and drug discovery applications.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| Unprotected Indole Group | Useful where Boc-protected tryptophan is not required |
| High Enantiomeric Purity | ≥99.0% for consistent stereochemical performance |
| SPPS Compatible | Suitable for incorporation of tryptophan residues into synthetic peptides |
| Research Applications | Ideal for peptide chemistry, proteomics, drug discovery, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Trp-OH, ≥98.0% HPLC |
| Synonym | Fmoc-protected L-tryptophan |
| CAS Number | 35737-15-6 |
| Empirical Formula | C₂₆H₂₂N₂O₄ |
| Molecular Weight | 426.46 g/mol |
| MDL Number | MFCD00037126 |
| UNSPSC Code | 12352209 |
| EC Index Number | 252-706-5 |
| Optical Activity | [α]²⁰/D -21 ± 2°; c = 1% in DMF |
| Form | Powder |
| Assay | ≥98.0% by HPLC |
| Enantiomeric Purity | ≥99.0% |
| Water Content | ≤1.0% by Karl Fischer titration |
| Storage Temperature | 2–30 °C |
| Functional Groups | Fmoc, amine, carboxylic acid |
Applications
Fmoc-Trp-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of tryptophan residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Proteomics and biochemical research
- Protein engineering and structural biology studies
- Fluorescence-based peptide and protein studies
- Enzyme-substrate and ligand-binding interaction studies
- Bioorganic chemistry and peptidomimetic synthesis
- Workflows requiring tryptophan without Boc side-chain protection
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 8522070005 | 5 g |
| 8522070100 | 100 g |
| 8522071000 | 1 kg |
Storage & Handling
Store at 2–30 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
- Pack Size: 1kg 100g 5g