0
Sigma-Aldrich™ Novabiochem® Fmoc-OSu ≥99.0% (HPLC), for peptide synthesis
Catalog No :
CAS Number :
Brand :
In Stock
Specifications:
| Application | Protein Biology, Peptide Synthesis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Amino Acid & Biochemicals | Forms | Powder |
| Product Brand | Sigma-Aldrich | ||
| Product Grade | HPLC Grade | Formula | C₁₉H₁₅NO₅ |
Fmoc-OSu, also known as N-(9-Fluorenylmethoxycarbonyloxy)succinimide, is a high-purity Fmoc transfer reagent used for amine protection, amino acid derivatization, peptide synthesis, and biomolecule functionalization. It is commonly used to introduce the Fmoc protecting group onto amino acids, peptides, and other amine-containing molecules.
As a reactive succinimidyl ester, Fmoc-OSu enables efficient and selective N-terminal or amine functionalization under suitable reaction conditions. It is widely used in Fmoc-based solid-phase peptide synthesis (SPPS), medicinal chemistry, bioorganic chemistry, chemical biology, biomaterial functionalization, and peptide reagent preparation.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥99.0% by HPLC for reliable synthetic performance |
| Fmoc Transfer Reagent | Introduces Fmoc protection onto amino acids, peptides, and amines |
| Reactive Succinimidyl Ester | Enables efficient and selective amine functionalization |
| SPPS Compatible | Useful in workflows supporting Fmoc-based peptide synthesis |
| Low Impurity Profile | Helps reduce unwanted byproducts in Fmoc derivatization |
| Versatile Research Use | Suitable for peptide chemistry, medicinal chemistry, biomaterials, and chemical biology |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-OSu, ≥99.0% HPLC |
| Full Name | N-(9-Fluorenylmethoxycarbonyloxy)succinimide |
| CAS Number | 82911-69-1 |
| Empirical Formula | C₁₉H₁₅NO₅ |
| Molecular Weight | 337.33 g/mol |
| MDL Number | MFCD00010733 |
| EC Index Number | 433-520-5 |
| UNSPSC Code | 12352108 |
| Form | Powder |
| Melting Point | 145–148 °C |
| Assay | ≥99.0% by HPLC |
| Storage Temperature | 2–8 °C |
| Functional Groups | Fmoc, succinimidyl ester |
Applications
Fmoc-OSu is suitable for:
- Preparation of Fmoc-protected amino acids
- Selective amine protection and functionalization
- Fmoc-based peptide synthesis workflows
- Amino acid derivatization
- Peptide and small-molecule modification
- Medicinal chemistry and drug discovery research
- Biomolecule and biomaterial functionalization
- Surface chemistry and synthetic biointerface design
- Chemical biology and bioengineering applications
- Sequence-defined peptide and polymer functionalization
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 8510140025 | 25 g |
| 8510140100 | 100 g |
| 8510141000 | 1 kg |
Storage & Handling
Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture, oxidation, strong acids, strong bases, and nucleophiles. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
- Pack Size: 1kg 100g 25g