Thermo Scientific™ Paclitaxel, 99.5%

Thermo Scientific™ Paclitaxel (≥99.5%) is a tetracyclic diterpenoid antineoplastic compound originally isolated from the Pacific yew tree (Taxus brevifolia).

A cornerstone of chemotherapeutic research, paclitaxel promotes microtubule polymerization while inhibiting depolymerization, thereby stabilizing microtubules and blocking mitotic spindle disassembly, leading to cell cycle arrest and apoptosis.

Paclitaxel is used in studies on cancer biology, drug delivery, and microtubule dynamics, as well as in biochemical assays and cell-based experiments investigating apoptosis, metastasis, and angiogenesis.

Key Features

• High Purity: ≥99.5% (HPLC) for consistent performance in cell-based assays.
• Mechanism of Action: Promotes tubulin polymerization and stabilizes microtubules, inhibiting mitosis.
• Antineoplastic Activity: Widely studied in models of breast, ovarian, lung, and pancreatic cancers.
• Multifunctional Reagent: Suitable for cell culture, molecular biology, and drug release studies.
• Reliable Research Grade: Validated for use in cancer biology, pharmacology, and nanomedicine applications.
• Storage: Store in a cool, dry place, protected from light and moisture.
• Research Use Only (RUO): Not for human or veterinary therapeutic applications.

Chemical Identifiers

Specifications

Applications

• Oncology Research: Evaluation of paclitaxel’s cytotoxic and antimitotic effects in tumor models.
• Pharmacology: Studies on tubulin stabilization, Bcl-2 modulation, and apoptotic signaling.
• Drug Delivery: Formulation of liposomal, nanoparticle, and micellar paclitaxel delivery systems.
• Cell Biology: Analysis of mitotic arrest and cell cycle checkpoint activation.
• Molecular Biology: Mechanistic studies of apoptosis and angiogenesis inhibition.

References

1. England, C.G. et al., “Release kinetics of paclitaxel and cisplatin from gold nanoparticles.” Eur. J. Pharm. Biopharm. (2015) 92, 120–129.
2. Liu, Y. et al., “Paclitaxel liposomes decorated with multifunctional tandem peptides for glioma targeting.” Biomaterials (2014) 35(17), 4835–4847.

Safety & Handling

• Signal Word: Danger
• Hazard Statements:
  • H315 – Causes skin irritation
  • H317 – May cause allergic skin reaction
  • H318 – Causes serious eye damage
  • H335 – May cause respiratory irritation
  • H361 – Suspected of damaging fertility or the unborn child
  • H413 – May cause long-lasting harmful effects to aquatic life
• Precautionary Statements:
  • P280 – Wear protective gloves/protective clothing/eye protection
  • P302 + P352 – If on skin: Wash with plenty of soap and water
  • P305 + P351 + P338 – If in eyes: Rinse cautiously with water; remove contact lenses
  • P310 – Immediately call a POISON CENTER or doctor

The Thermo Scientific™ Paclitaxel (≥99.5%) is a high-purity microtubule stabilizer and antineoplastic compound used extensively in cancer research and drug development.

By inhibiting mitosis and inducing apoptosis through microtubule stabilization, it remains a critical reagent for oncology, pharmacology, and molecular biology studies, supporting reliable and reproducible results in chemotherapeutic research.