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Thermo Scientific™ Camptothecin, (HPLC) >90%
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Cytotoxic antitumor agent that inhibits topoisomerase I
Specifications:
| Application | Cell Analysis, Apoptosis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Biochemical Reagent | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₂₀H₁₆N₂O₄ |
Thermo Scientific™ Camptothecin is a cytotoxic plant alkaloid and a potent DNA topoisomerase I inhibitor with well-established anticancer properties.
This compound interferes with the re-ligation step of the topoisomerase I-mediated DNA cleavage-rejoining process, leading to DNA strand breaks, cell cycle arrest, and apoptosis in rapidly dividing cells.
Originally isolated from Camptotheca acuminata, camptothecin is used in oncology research and serves as the parent compound for clinically approved chemotherapeutic analogues such as irinotecan and topotecan.
Key Features
- Cytotoxic Antitumor Agent: Induces apoptosis via DNA damage through topoisomerase I inhibition.
- High Purity: >90% purity by HPLC.
- Research Use: Suitable for in vitro cancer and cell biology studies.
- Reference Compound: Basis for drug design and evaluation of camptothecin derivatives.
- Storage: Stable at 2–8 °C in tightly closed containers.
- Research Use Only (RUO): Not for therapeutic or diagnostic applications.
Chemical Identifiers
| Property | Value |
|---|---|
| Chemical Name (IUPAC) | (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione |
| Synonyms | Camptothecin, 20(S)-Camptothecin, (+)-Camptothecine, CPT |
| CAS Number | 7689-03-4 |
| Molecular Formula | C₂₀H₁₆N₂O₄ |
| Molecular Weight | 348.36 g/mol |
| InChI Key | VSJKWCGYPAHWDS-FQEVSTJZSA-N |
| SMILES | CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=C1N=C1C=CC=CC1=C3)C2=O |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | >90% |
| Form | Powder |
| Appearance | Yellow powder |
| Mechanism of Action | DNA Topoisomerase I inhibition |
| Storage Conditions | 2–8 °C, dry and light-protected |
| Packaging | Glass bottle |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer Research: Evaluation of antitumor mechanisms and cytotoxicity.
- Drug Discovery: Screening of camptothecin derivatives and analogues.
- Cell Biology: Induction of DNA damage and apoptosis in cell lines.
- Pharmacology: Investigating the molecular mechanisms of topoisomerase I inhibitors.
- Medicinal Chemistry: Precursor for semi-synthetic anticancer drugs (irinotecan, topotecan).
References
- Wall, M.E. et al. “Camptothecin: Discovery of a new antitumor agent.” Cancer Chemother Rep. (1966) 50(6): 261–270.
- Pommier, Y. “Topoisomerase I inhibitors: Camptothecins and beyond.” Nat Rev Cancer. (2006) 6, 789–802.
The Thermo Scientific™ Camptothecin is a high-quality, research-grade topoisomerase I inhibitor widely used as a model antitumor compound.
Its proven efficacy in inducing DNA strand breaks and apoptosis makes it an indispensable reagent for oncology, pharmacological, and cellular mechanism research.
- Pack Size: 250mg 1g 5g