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Thermo Scientific™ Etoposide, ≥95.0%
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Topoisomerase inhibitor and inducer of apoptosis
Specifications:
| Application | cell Signalling, Apoptosis | ||
| Storage Temperature | -20°C | ||
| Product Type | Biochemical Reagent | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₂₉H₃₂O₁₃ |
Thermo Scientific™ Etoposide (≥95%) is a cytotoxic topoisomerase II inhibitor widely used in cancer, molecular biology, and pharmacological research.
It inhibits DNA synthesis and repair by stabilizing the DNA–enzyme complex, causing strand breaks and apoptosis, especially in cells during the late S and G₂ phases of the cell cycle.
Etoposide is an essential reference compound for oncology and apoptosis studies, supporting mechanistic research into DNA damage response, cell cycle control, and drug resistance.
Key Features
- High Purity: ≥95% assay (HPLC).
- Mechanism of Action: Inhibits topoisomerase II, preventing re-ligation of cleaved DNA strands.
- Cell Cycle Specificity: Active against cells in late S and G₂ phases.
- Cytotoxic and Apoptotic Inducer: Induces programmed cell death in tumor cell models.
- Research Grade: Ideal for cancer biology, pharmacology, and mechanistic cell assays.
- Solubility: Insoluble in water; soluble in DMSO.
- Storage: Stable in DMSO at 4 °C for short-term; aliquots at −20 °C for long-term storage.
- Safety Classification: Carcinogenic (Category 1A); handle with appropriate PPE.
- Research Use Only (RUO): Not for diagnostic or therapeutic use.
Chemical Identifiers
| Property | Value |
|---|---|
| IUPAC Name | (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one |
| Synonyms | VP-16, VePesid, α-D-Glucopyranosyl isomer of Etoposide |
| CAS Number | 33419-42-0 |
| Molecular Formula | C₂₉H₃₂O₁₃ |
| Molecular Weight | 588.56 g/mol |
| InChI Key | VJJPUSNTGOMMGY-MRVIYFEKSA-N |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | ≥95% |
| Form | Powder or crystalline solid |
| Color | White to off-white |
| Infrared Spectrum | Conforms |
| Solubility | Insoluble in water; soluble in DMSO |
| Storage Conditions | 4 °C (DMSO solution); −20 °C (long-term) |
| Hazard Classification | Acute Oral Toxicity Cat. 4; Carcinogenicity Cat. 1A |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer and Oncology Research: Mechanistic studies on apoptosis, DNA damage, and topoisomerase inhibition.
- Cell Cycle Analysis: Investigation of S/G₂ phase arrest and replication stress.
- Pharmacology and Toxicology: Model compound for chemotherapeutic mechanism evaluation.
- Molecular Biology: DNA repair, transcriptional regulation, and checkpoint pathway analysis.
- Drug Discovery: Used in screening and validation of DNA-interacting anticancer compounds.
References
- Hande, K.R. “Etoposide: Four decades of development of a topoisomerase II inhibitor.” Eur. J. Cancer (1998), 34(10), 1514–1521.
- Slevin, M.L. “The clinical pharmacology of etoposide.” Recent Advances in Etoposide Therapy (1991), 319–329.
The Thermo Scientific™ Etoposide (≥95%) is a topoisomerase II inhibitor and apoptosis inducer used in fundamental and applied cancer research.
With high purity, reproducible performance, and strong mechanistic relevance, it is a key reagent for exploring DNA damage responses, cell cycle control, and antitumor pathways.
- Pack Size: 25mg 100 mg