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Thermo Scientific™ Orbitrap™ Excedion™ Pro Mass Spectrometer
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Configured for metabolomics, lipidomics, proteomics, and structural biology
Specifications:
| Application | molecular biology, Proteomics, Metabolomics, Lipidomics, Biopharmaceutical Research | Warranty | 2 Years |
| Storage Temperature | Ambient | ||
| Product Type | Analytical Instrument | ||
| Product Brand | Thermo Fisher Scientific™ | ||
| Product Grade | Analytical grade | ||
The Thermo Scientific™ Orbitrap™ Excedion™ Pro Mass Spectrometer is a next-generation hybrid Orbitrap LC-MS platform engineered to support advanced research in metabolomics, lipidomics, proteomics, structural biology, and biopharma characterization. Designed for scientists who require exceptional sensitivity, high mass accuracy, deep analytical coverage, and flexible fragmentation capabilities, this system enables confident identification, quantification, and structural elucidation of complex biomolecules.
Built to deliver outstanding performance across diverse workflows, the Orbitrap Excedion Pro combines high resolution of up to 480,000 at m/z 200, extended dynamic range, and multiplexing of up to 20 precursor ions per scan. It supports both routine and cutting-edge research, from deep proteome profiling and PTM analysis to non-targeted metabolomics, lipidomics discovery, and higher-order structural analysis of biomolecules.
The platform is also available in a BioPharma configuration, offering extended mass detection up to m/z 12,000 for characterization of large biomolecules and structural biology applications. Optional Electron Transfer Dissociation (ETD) and Electron-Transfer/Higher-Energy Collision Dissociation (EThcD) provide powerful alternative fragmentation strategies for detailed molecular analysis, including Asp/IsoAsp isomerization detection, leucine/isoleucine differentiation, HDX workflows, and middle-down/top-down proteomics.
Key Features
- High-performance hybrid Orbitrap LC-MS system for advanced omics and structural biology research
- Supports metabolomics, lipidomics, proteomics, and biopharma characterization
- Delivers up to 480,000 resolution at m/z 200 for precise mass analysis
- Provides excellent sensitivity with detection limits below 1.5 fg reserpine on column
- Features 5 orders of magnitude intrascan dynamic range
- Enables multiplexing of up to 20 precursor ions per scan
- Standard HCD fragmentation for b/y ion analysis
- Optional ETD and EThcD fragmentation for c/z ion generation and advanced structural elucidation
- Supports HDX-MS workflows for protein conformation and interaction studies
- Enables deep proteome coverage, Hybrid-DIA, PTM analysis, and immunopeptidomics
- Improves metabolomics and lipidomics discovery with increased sensitivity and enhanced dynamic range (eDR)
- BioPharma model supports mass detection up to m/z 12,000
- Stable mass accuracy with <3 ppm RMS drift over at least 4 weeks and <1 ppm RMS drift using lock mass and EASY-IC under defined conditions
Applications
The Orbitrap Excedion Pro Mass Spectrometer is ideal for:
- Proteomics research
- Post-translational modification (PTM) analysis
- Hybrid-DIA workflows
- Immunopeptidomics
- Non-targeted metabolomics
- Lipidomics profiling
- Biopharmaceutical characterization
- Top-down and middle-down mass spectrometry
- Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)
- Structural biology and conformational analysis
- Protein-protein interaction studies
Technical Specifications
| Parameter | Specification |
|---|---|
| Product Name | Thermo Scientific™ Orbitrap™ Excedion™ Pro Mass Spectrometer |
| Catalog Number | BRE725572 |
| Type | Orbitrap LC-MS |
| Model | Orbitrap Excedion Pro Mass Spectrometer for metabolomics, lipidomics, proteomics, and structural biology |
| Max Resolution | Up to 480,000 at m/z 200 |
| Dynamic Range | 5 orders of magnitude intrascan dynamic range |
| Multiplexing | Up to 20 precursor ions per scan |
| Fragmentation | Standard HCD; Optional ETD field upgrade |
| Detection Limit (Full Scan) | < 1.5 fg reserpine on column |
| Detection Limit (MS2) | < 1.5 fg reserpine on column |
| Detection Limit (SIM) | < 0.8 fg reserpine on column |
| Mass Accuracy | <3 ppm RMS drift over at least 4 weeks; <1 ppm RMS drift over 24 hours with lock mass; <1 ppm RMS drift for at least 5 days with EASY-IC |
| Dimensions (D × W × H) | 29.8 × 21 × 27.6 in. (758 × 535 × 703 mm) |
| Unit Size | Each |
Unique Advantages
The Orbitrap Excedion Pro stands out as a highly versatile mass spectrometry platform that bridges traditional high-resolution LC-MS workflows with advanced structural biology and biopharma analysis. Its combination of ultrahigh resolution, excellent sensitivity, broad dynamic range, and optional ETD/EThcD fragmentation makes it especially valuable for laboratories seeking a future-ready platform capable of tackling increasingly complex analytical challenges.
For researchers in proteomics, it enables deeper proteome coverage, improved PTM analysis, and advanced immunopeptidomics. For metabolomics and lipidomics users, it offers enhanced sensitivity and improved unknown compound annotation. In structural biology and biopharma, it brings powerful tools for higher-order structure characterization, HDX-MS, and confident characterization of large biomolecules.
The Thermo Scientific™ Orbitrap™ Excedion™ Pro Mass Spectrometer is a premium analytical solution for laboratories that demand superior performance in high-resolution mass spectrometry. Whether your focus is proteomics, metabolomics, lipidomics, structural biology, or biopharma characterization, this system provides the sensitivity, accuracy, fragmentation flexibility, and analytical depth required to drive meaningful scientific discovery.