Thermo Scientific™ EASY-Spray™ Nano Ion Source (NG)

The Thermo Scientific™ EASY-Spray™ Nano Ion Source (NG) is an advanced nano-electrospray ionization (nano-ESI) solution designed to deliver exceptional LC-MS sensitivity, robustness, and reproducibility for high-performance proteomics and biomolecular analysis. Engineered with an integrated column-emitter design, this system eliminates complex and error-prone connections typical of nanoflow LC-MS setups, enabling consistent, high-quality results with simplified operation.

By combining nanoflow HPLC separations with precision-controlled nano-electrospray ionization, the EASY-Spray NG source ensures narrow chromatographic peaks, enhanced separation efficiency, and maximum detection sensitivity. Its temperature-controlled column-emitter units require only a single, tool-free connection, significantly reducing setup time, minimizing dead volume, and improving analytical reproducibility—even across multi-site studies.

Designed for compatibility with next-generation Thermo Scientific mass spectrometers, the EASY-Spray NG source is ideal for laboratories seeking reliable, high-throughput, and high-sensitivity LC-MS workflows.

Key Features

• Integrated column-emitter design eliminates multiple connections and reduces system complexity
• Temperature-controlled operation ensures stable and reproducible nano-ESI performance
• Single, tool-free connection simplifies setup and column replacement
• Zero-dead-volume fittings improve chromatographic efficiency and reliability
• Highly stable ionization for consistent long-term LC-MS performance
• Exceptional sensitivity for low-abundance analyte detection
• High peak capacity supports use of smaller particle sizes and longer columns
• Superior column-to-column reproducibility, ideal for large-scale or multi-site studies
• Designed for both expert and non-expert users

Applications

The EASY-Spray Nano Ion Source (NG) is optimized for:

• Proteomics and deep proteome profiling
• Peptide mapping and protein identification
• Biopharmaceutical characterization
• Post-translational modification (PTM) analysis
• Nanoflow LC-MS workflows
• Low-abundance biomolecule detection
• High-sensitivity omics research (proteomics, metabolomics, lipidomics)
• High-throughput LC-MS analysis in research and clinical environments

Technical Specifications

Instrument Compatibility (NG Version)

The EASY-Spray NG ion source is compatible with next-generation Thermo Scientific systems, including:

• Thermo Scientific Orbitrap Fusion Tribrid Mass Spectrometer
• Thermo Scientific TSQ Endura Triple-stage Quadrupole Mass Spectrometer
• Thermo Scientific TSQ Quantiva Triple-stage Quadrupole Mass Spectrometer

Unique Advantages

The EASY-Spray Nano Ion Source (NG) transforms nanoflow LC-MS workflows by addressing one of the most common challenges: system complexity and variability due to multiple fluidic connections. Its integrated column-emitter architecture ensures optimal alignment and minimizes dead volume, resulting in improved chromatographic performance and enhanced MS sensitivity.

By reducing setup complexity and improving reproducibility, the system enables laboratories to achieve consistent, high-quality data, even in demanding applications such as large-scale proteomics studies and multi-site collaborations. Its temperature-controlled design further enhances stability, making it a reliable solution for extended analytical runs.

The Thermo Scientific™ EASY-Spray™ Nano Ion Source (NG) is a powerful and user-friendly solution for laboratories seeking to maximize the performance of their LC-MS systems. With its integrated design, superior sensitivity, and exceptional reproducibility, it is an essential tool for advancing proteomics, biopharma analysis, and high-sensitivity omics research.