Thermo Scientific™ Theophylline-7-acetic acid ≥98%

Theophylline-7-acetic acid is a synthetic xanthine derivative of theophylline, commonly used in medicinal chemistry and pharmaceutical research. Structurally similar to methylxanthines like theophylline and caffeine, this compound features a carboxymethyl side chain at the N-7 position, altering its solubility, binding affinity, and pharmacokinetics.

It is valued as a building block and intermediate in the synthesis of theophylline-based drugs and analogs, and is studied for its role in bronchodilation, phosphodiesterase inhibition, and adenosine receptor modulation.

Available Pack Sizes

Chemical and Physical Properties

Applications in Research

Theophylline-7-acetic acid is primarily used in:

• Medicinal chemistry
  • Intermediate for the synthesis of xanthine-based therapeutic agents, including bronchodilators and vasodilators
  • Scaffold for analogs in adenosine receptor antagonist development
• Pharmacological and biochemical studies
  • Explored for potential PDE inhibition and smooth muscle relaxation
  • Structural analog for comparative SAR (structure-activity relationship) analyses in methylxanthine research
• Chemical synthesis & modification
  • Functionalized for improved solubility or altered lipophilicity
  • Base compound for formulation into salt forms or conjugates

Handling and Preparation

• Storage: Store in a cool, dry place at ambient temperature
• Reconstitution: Soluble in ethanol and moderately soluble in water; prepare fresh solutions as needed
• Stability: Stable under recommended storage and handling conditions; sensitive to strong acids and bases

Thermo Scientific™ Theophylline-7-acetic acid (≥98%) is a high-quality research compound ideal for drug development, chemical modification, and methylxanthine-related signaling studies. With a well-characterized purity profile, solid-state stability, and relevance as a chemical intermediate, this compound is an indispensable tool for researchers focused on respiratory pharmacology, adenosine receptor biochemistry, and xanthine-based drug discovery.