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Thermo Scientific™ Serotonin hydrochloride 97+%
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Specifications:
| Application | Protein Biology, cell Signalling | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Laboratory Chemical | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₁₀H₁₃ClN₂O |
Serotonin hydrochloride is the hydrochloride salt form of serotonin, a biogenic monoamine neurotransmitter found extensively in both central (CNS) and peripheral nervous systems (PNS). It plays critical roles in regulating mood, sleep, appetite, thermoregulation, cardiovascular function, endocrine activity, gastrointestinal motility, and cognition. It is also widely studied for its involvement in various neuropsychiatric conditions such as depression, anxiety, schizophrenia, and obsessive-compulsive disorder (OCD).
This product is supplied as a white to off-white crystalline powder with ≥97.5% purity (determined by argentometric titration) and is suitable for both cell-based and biochemical assays.
Key Specifications
| Property | Specification |
|---|---|
| Purity (Titration) | ≥97.5% |
| Form | Crystalline powder |
| Color | White to off-white |
| Melting Point | 168–172 °C |
| Loss on Drying | ≤2.5% (at 115 °C under vacuum for 3 hours) |
| Appearance in Methanol (1%) | Clear to slightly hazy solution |
| Solubility | Soluble in water and methanol |
| Storage | Store at 2–8 °C, protected from light and moisture |
Available Pack Sizes
| Catalog Number | Pack Size | Container Type |
|---|---|---|
| 215021000 | 100 mg | Glass bottle |
| 215025000 | 500 mg | Glass bottle |
Biochemical and Physiological Actions
Serotonin hydrochloride functions as an endogenous neurotransmitter and hormone, influencing multiple systems:
- Central Nervous System: Regulates mood, emotion, aggression, sleep-wake cycle, appetite, memory, and pain perception
- Peripheral Nervous System: Modulates vascular tone, gastrointestinal motility, and endocrine secretion
- Developmental Biology: Involved in neural circuit formation, axonal guidance, and synaptogenesis
In research, serotonin is critical for studying:
- 5-HT receptor pharmacology
- Biogenic amine transporters
- Neuroplasticity and neuromodulation
- Neurodevelopmental and neurodegenerative disorders
Applications
Serotonin hydrochloride has been used in a range of biological and pharmacological research studies:
- Liver spheroid fibrosis studies via 5-HT receptor modulation
- ERK phosphorylation pathway analysis in HEK293 cells
- Colon cancer models, including transwell migration, wound healing, and tumor allograft assays
- Studies of serotonin’s role in mitogenesis, cell proliferation, and signal transduction
- Experimental modulation of serotoninergic tone in behavioral and cognitive neuroscience
Usage and Handling Notes
- Preparation: Dissolve in sterile water or methanol before use; prepare fresh solutions as needed
- Storage: Store powder at 2–8 °C; protect from light and moisture
- Reconstitution: Aliquot solutions if long-term storage is required to avoid multiple freeze-thaw cycles
Thermo Scientific™ Serotonin Hydrochloride (≥97%) is a reliable and high-purity reagent ideal for use in neuroscience, psychiatric, pharmacological, gastrointestinal, and cardiovascular research. With a well-established biological profile, this compound supports a wide range of applications from receptor pharmacology to cell signaling and disease modeling. Whether studying neurotransmitter pathways, psychiatric disorders, or drug interactions, serotonin hydrochloride remains an essential research-grade biochemical tool.
- Pack Size: 100mg 500mg