Thermo Scientific™ Hydrocortisone 98%

Hydrocortisone is the primary glucocorticoid hormone secreted by the adrenal cortex, crucial for carbohydrate metabolism, immune modulation, and stress response. With three times the anti-inflammatory potency of corticosterone but much lower sodium-retaining activity, it plays a central role in inflammatory suppression and immune regulation.

Thermo Scientific provides research-grade hydrocortisone at ≥98% HPLC purity, suitable for biochemical, pharmacological, cell-based, and analytical research.

Available Pack Sizes

Chemical and Physical Specifications

Biological & Pharmacological Profile

Hydrocortisone functions as:

• A natural corticosteroid: Secreted by the adrenal glands, regulating metabolic, cardiovascular, and immune functions
• Anti-inflammatory agent: Inhibits leukocyte infiltration, cytokine expression, and prostaglandin synthesis
• Immunosuppressant: Used in models of allergic reactions, autoimmune diseases, and inflammation
• Stress hormone: Plays a role in gluconeogenesis, blood pressure regulation, and adrenal feedback loops

Compared to other corticosteroids:

• Higher anti-inflammatory potency than corticosterone
• Lower sodium (Na⁺) retention activity, making it more targeted for immunological effects

Applications in Research

• Inflammation and Immune Response Studies
  • Modulates NF-κB, cytokine signaling, and leukocyte activation
• Endocrine Physiology and Hormone Replacement Models
  • Used in adrenal insufficiency, HPA axis, and glucocorticoid response research
• Cellular Stress and Metabolism Assays
  • Regulates gene expression for glucose metabolism and protein catabolism
• Dermatology and Wound Healing Models
  • Anti-inflammatory action in skin cell cultures and fibroblast assays
• Cancer Biology and Apoptosis Studies
  • Investigated for its role in cell cycle regulation and immune evasion

Storage & Handling

• Storage Temperature: Ambient
• Solubility: Slightly soluble in water; soluble in ethanol, methanol, and acetone
• Stability: Store in a dry, light-protected container; stable under normal lab conditions

Thermo Scientific™ Hydrocortisone (≥98%) is a high-purity, research-grade glucocorticoid that supports advanced studies in immunology, endocrinology, metabolism, and inflammation. Its well-defined anti-inflammatory profile and minimal mineralocorticoid activity make it an essential standard for hormonal response assays, cell signaling studies, and drug screening applications.