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Specifications:
| Application | Apoptosis | ||
| Storage Temperature | -20°C | ||
| Product Type | Enzymes and Substrates | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₂₈H₄₀N₂O₉ |
Thermo Scientific™ Antimycin A is a potent mitochondrial electron transport inhibitor isolated from Streptomyces species. It acts specifically at Complex III (cytochrome bc₁ complex) of the mitochondrial respiratory chain, blocking electron transfer between cytochromes b and c₁.
This biochemical reagent is widely used to investigate mitochondrial reactive oxygen species (ROS) production, cell respiration mechanisms, and oxidative stress in mammalian cells and isolated mitochondria.
It is a high-purity, research-grade compound for advanced studies in bioenergetics, oxidative metabolism, and mitochondrial physiology.
Key Features
- Mechanistic Inhibitor: Targets the cytochrome bc₁ complex (Complex III) in mitochondria.
- Research Utility: Commonly used to study ROS generation, oxidative phosphorylation, and cellular respiration.
- Source: Isolated from Streptomyces species.
- High Purity: Fine, white to pale yellow crystalline powder.
- Solubility: Soluble in 100% ethanol; insoluble in water.
- Research Use Only: For biochemical and molecular biology applications; not for human or animal use.
Chemical Identifiers
| Property | Value |
|---|---|
| Chemical Name (IUPAC) | (2R,3S,6S,7R,8R)-3-(3-formamido-2-hydroxybenzamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate |
| Synonyms | Antimycin A₁, Fintrol, Virosin, Antipiricullin |
| CAS Number | 1397-94-0 |
| Molecular Formula | C₂₈H₄₀N₂O₉ |
| Molecular Weight | 548.63 g/mol |
| InChI Key | UIFFUZWRFRDZJC-SBOOETFBSA-N |
| SMILES | CCCCCCC[C@@H]1C@@HC@HOC(=O)C@@HC@@HOC1=O |
Specifications
| Parameter | Specification |
|---|---|
| Form | Powder |
| Appearance (Color) | White to pale yellow |
| Purity | High purity (as per Alfa Aesar standard) |
| Solubility | Soluble in ethanol; insoluble in water |
| Origin | Isolated from Streptomyces sp. |
| Storage Conditions | Store at 2–8 °C, tightly sealed and desiccated |
| Intended Use | Research Use Only (RUO) |
Applications
- Study of mitochondrial function and bioenergetics
- Analysis of oxidative stress and reactive oxygen species production
- Investigation of Complex III inhibition in electron transport chain research
- Assessment of cellular metabolism, apoptosis, and energy regulation
- Comparative studies in tissue-specific mitochondrial dysfunction, including COPD, cardiovascular disease, and neurodegeneration research
References
- Tappel, A.L. Biochemical Pharmacology (1960) 4, 289–296.
- Sakajo, S. et al. Biochimica et Biophysica Acta (BBA) – Gene Structure and Expression (1991) 1, 102–108.
The Thermo Scientific™ Antimycin A is a trusted, high-purity mitochondrial research inhibitor used to dissect respiratory chain function, ROS generation, and oxidative metabolism.
Its well-characterized inhibitory action on the cytochrome bc₁ complex makes it an essential reagent for biochemical, cellular, and physiological research investigating energy metabolism and mitochondrial pathology.
- Pack Size: 10mg 5mg