Sigma-Aldrich Suramin sodium salt ≥98% (TLC)

Suramin sodium salt  is a polysulfonated naphthylurea compound widely used in biomedical, parasitological, and molecular biology research. Originally developed as an antiparasitic drug for treating trypanosomiasis and onchocerciasis, Suramin exhibits a broad spectrum of biological and pharmacological activities, including anticancer, antiangiogenic, and neuroprotective effects.

With a molecular weight of 1429.17 g/mol and ≥98% purity verified by TLC (Thin Layer Chromatography), this Sigma-Aldrich product is ideal for receptor pharmacology, signal transduction studies, glial biology, and purinoceptor pathway research.

Key Features & Benefits

✅ Pharmaceutical-Grade Purity

• ≥98% purity confirmed by TLC ensures consistent performance in sensitive assays.

✅ Multi-Target Biological Activity

• Acts as a broad-spectrum P2X and P2Y purinergic receptor antagonist.
• Inhibits topoisomerase II, growth factor signaling, and heparanase.

✅ Applications in Neuroscience and Oncology

• Demonstrated effects on glial activity, tyrosine phosphorylation, and neuroprotection in experimental models.
• Antitumor and antiangiogenic properties useful in cancer biology research.

✅ Versatile Research Applications

• Used in electrophysiology, receptor inhibition, parasite studies, and neurodegenerative disease models.

Applications

• Purinergic Receptor Blockade: Inhibits P2Y2 and other purinoceptors to elucidate ATP signaling pathways.
• Electrophysiological Studies: Assesses ion transport effects (e.g., short circuit current across strial marginal cells).
• Neurobiology: Explores glial activation, neuroinflammation, and neuroprotective mechanisms.
• Cancer Research: Investigates antiproliferative and antiangiogenic properties, particularly via FGFa, FGFb, and PDGF inhibition.
• Parasitology & Tropical Medicine: Studies the pharmacodynamics of trypanosomiasis and onchocerciasis treatment.

Biochemical/Physiological Actions

• Inhibits tumor cell proliferation
• Blocks topoisomerase II-DNA interaction
• Antagonizes growth factor binding and signaling (FGF, PDGF)
• Disrupts G-protein-receptor coupling
• Exhibits broad antiparasitic and anthelmintic effects

Product Specifications

Available Pack Sizes

Storage & Handling

• Store in a dry, cool environment, sealed tightly.
• Avoid exposure to light and moisture.
• Use appropriate PPE during handling.
• For laboratory use only – not for drug, household, or other human use.

Sigma-Aldrich Suramin Sodium Salt is a robust and versatile biochemical tool for advanced research in receptor biology, oncology, neuroscience, and parasitology. Its high purity, broad-spectrum activity, and documented applications make it a trusted choice for researchers requiring precision, reproducibility, and biological relevance in their experiments.