Sigma-Aldrich Fmoc-Ser(tBu)-OH ≥98.0% (HPLC), for peptide synthesis

Fmoc-Ser(tBu)-OH, also known as Fmoc-protected serine tert-butyl ether, is a high-purity, selectively protected serine derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group and a tert-butyl-protected hydroxyl side chain, enabling controlled peptide elongation while preventing unwanted side reactions involving the serine hydroxyl group.

This reagent is widely used in custom peptide synthesis, pharmaceutical research, proteomics, drug discovery, protein engineering, synthetic biology, and bioconjugation chemistry. Its protected structure supports efficient incorporation of serine residues into linear, cyclic, and modified peptides.

Key Features

Chemical Properties & Identifiers

Applications

Fmoc-Ser(tBu)-OH is suitable for:

• Fmoc-based solid-phase peptide synthesis
• Incorporation of serine residues into synthetic peptides
• Linear and cyclic peptide synthesis
• Custom peptide synthesis and peptide modification
• Peptide-based pharmaceutical and drug discovery research
• Protein engineering and proteomics research
• Bioconjugation and bioactive molecule design
• Synthetic biology and bioorganic chemistry workflows
• Synthesis of complex peptides and peptide fragments

Ordering Information

Storage & Handling

Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture, oxidizing agents, and direct sunlight. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.

Research Use Statement

For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.