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Invitrogen™ CD147 (Soluble) Monoclonal Antibody (MEM-M6/6)
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Specifications:
| Application | Western Blot, ELISA-Based Assays, Flow Cytometry, Functional Assay (FN) | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Primary Antibodies | Forms | Liquid |
| Product Brand | Thermo Fisher Scientific™, Invitrogen | ||
| Product Grade | Molecular Biology | ||
The Invitrogen™ CD147 (Soluble) Monoclonal Antibody (Clone MEM-M6/6) is a high-quality mouse IgG1 antibody developed for the detection and functional study of human CD147 (Basigin/EMMPRIN). CD147 is a highly glycosylated type I transmembrane protein widely expressed on leukocytes, red blood cells, platelets, and endothelial cells, and is strongly associated with metabolically active and malignant tumor cells.
This antibody recognizes the extracellular immunoglobulin domain D2 of CD147 and is validated for applications including flow cytometry, western blotting, ELISA, and functional inhibition assays. Supplied as a purified, unconjugated liquid preparation, it is suitable for both routine immunological workflows and advanced cancer and extracellular matrix research.
Key Features
- Monoclonal antibody specific for human CD147 (Basigin/EMMPRIN)
- Clone: MEM-M6/6 (Mouse IgG1)
- Recognizes extracellular Ig domain D2 (membrane proximal region)
- Validated for Flow Cytometry, WB, ELISA, and Functional assays
- Protein A purified with very low endotoxin levels
- Ideal for immunology, oncology, and cell metabolism studies
- Compatible with secondary antibody-based detection systems
Applications
| Application | Recommended Use |
|---|---|
| Flow Cytometry | 1–4 µg/mL |
| Western Blot | Assay-dependent (non-reducing conditions recommended) |
| ELISA | Suitable (publication-supported) |
| Functional Assays | Assay-dependent (Inhibition studies) |
Product Specifications
| Parameter | Specification |
|---|---|
| Product Name | CD147 (Soluble) Monoclonal Antibody |
| Catalog Number | MA1-10103 |
| Clone | MEM-M6/6 |
| Host Species / Isotype | Mouse / IgG1 |
| Species Reactivity | Human |
| Format | Unconjugated |
| Concentration | 1 mg/mL |
| Purification Method | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Preservative | None |
| Endotoxin Level | <0.01 EU/µg |
| Storage Conditions | 4°C (Do not freeze) |
| Shipping Conditions | Ambient (Domestic); Wet ice (International) |
| Unit Size | 100 µg |
Target Information: CD147 (Basigin/EMMPRIN)
CD147 is also known as:
- Basigin
- Neurothelin
- EMMPRIN (Extracellular Matrix Metalloproteinase Inducer)
- Tumor cell-derived collagenase stimulatory factor
CD147 plays critical roles in:
- Regulation of extracellular matrix metalloproteinases (MMPs)
- Tumor invasion and metastasis
- Cell activation and immune responses
- Lactate transport via monocarboxylate transporters (MCTs)
- Embryo implantation and neural development
High CD147 expression is frequently associated with cancer progression and inflammation.
Recommended Handling
- Store at 4°C upon receipt
- Do not freeze (product contains no preservative)
- Use appropriate secondary antibodies for detection in Flow or ELISA
Regulatory Status
For Research Use Only. Not for use in diagnostic procedures.
The Invitrogen™ CD147 (Soluble) Monoclonal Antibody (MEM-M6/6), MA1-10103 is a reliable and well-characterized reagent for detecting and studying CD147 in human immune cells, endothelial biology, and cancer research. With validated performance in flow cytometry, ELISA, and functional inhibition studies, it is an essential tool for investigations into extracellular matrix remodeling, tumor metabolism, and immune activation pathways.