Liofilchem™ MTS™ Trimethoprim-sulfamethoxazole (1:19) SXT 0.002-32, MIC Test strips

The Liofilchem™ MTS™ Trimethoprim-Sulfamethoxazole (1:19) SXT MIC Test Strips are advanced diagnostic tools designed to determine the Minimum Inhibitory Concentration (MIC) of Trimethoprim-Sulfamethoxazole (TMP-SMX), a widely used antibiotic combination. With a MIC range of 0.002–32 μg/mL, these gradient diffusion strips provide precise and reliable results, essential for clinical diagnostics, antimicrobial resistance monitoring, and research.

Key Features

1. Wide MIC Range

• Covers concentrations from 0.002 to 32 μg/mL, enabling detection of low- and high-level resistance in bacterial pathogens.

2. Gradient Diffusion Technology

• Utilizes a stable TMP-SMX gradient to ensure precise MIC determination.
• Offers a quantitative method for susceptibility testing without the need for complex dilution techniques.

3. Therapeutic Ratio

• Each strip contains TMP-SMX in a 1:19 ratio, reflecting clinical dosing standards for accurate testing.

4. Broad Pathogen Coverage

• Effective against Gram-positive and Gram-negative bacteria, including:
  • Escherichia coli, Klebsiella spp., Proteus spp., Salmonella spp., Shigella spp.
  • Gram-positive bacteria like Staphylococcus aureus (including MRSA) and Streptococcus pneumoniae.

5. Compliance with Global Standards

• Fully compliant with international guidelines such as EUCAST and CLSI, ensuring reproducibility and consistency.

6. Fast Turnaround

• Results available within 16–24 hours, enabling timely clinical decision-making.

7. Easy-to-Use

• Simple application on agar plates with clear visual interpretation of MIC endpoints.

Applications

1. Clinical Diagnostics

• Assess bacterial susceptibility to TMP-SMX for treating infections like:
  • Urinary tract infections (UTIs).
  • Respiratory infections.
  • Gastrointestinal infections.
  • Skin and soft tissue infections.

2. Antimicrobial Resistance Surveillance

• Monitor trends in TMP-SMX resistance in clinical and public health settings.

3. Research and Development

• Investigate TMP-SMX efficacy and resistance mechanisms in experimental studies or pharmaceutical development.

4. Infection Control

• Identify multidrug-resistant pathogens in hospital environments to guide infection control strategies.

How It Works

1. Sample Preparation:
   • Prepare a bacterial suspension standardized to 0.5 McFarland.
2. Application:
   • Inoculate a Mueller-Hinton agar plate uniformly with the bacterial suspension.
   • Place the TMP-SMX MTS strip on the inoculated plate.
3. Incubation:
   • Incubate at 35–37°C for 16–24 hours.
4. Result Interpretation:
   • Read the MIC value where the elliptical zone of inhibition intersects the strip’s gradient scale.

Specifications

Advantages

1. Accuracy

• Gradient diffusion technology ensures precise and reliable MIC determination.

2. Speed

• Delivers actionable results within one day, facilitating timely therapeutic interventions.

3. Versatility

• Suitable for routine clinical diagnostics, antimicrobial resistance surveillance, and research.

4. Quality

• Manufactured under strict quality control to ensure consistent performance and long shelf life.

Limitations

• May require additional molecular testing to confirm resistance mechanisms.
• Not suitable for organisms that do not grow well on standard media.

Why Choose Liofilchem™ MTS™ Trimethoprim-Sulfamethoxazole?

• Comprehensive Testing: Covers a broad MIC range for effective susceptibility testing.
• Compliance: Meets global standards for consistent and reliable performance.
• Efficiency: Streamlines workflows with rapid and accurate results.

The Liofilchem™ MTS™ Trimethoprim-Sulfamethoxazole (1:19) SXT MIC Test Strips are indispensable tools for clinical microbiology labs, providing precise and efficient testing for TMP-SMX susceptibility and resistance detection.