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Ethyl acetate ≥99.8%, HiPerSolv CHROMANORM® for HPLC
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Filtered through a 0.2 µm filter, packaged under nitrogen.
Formula: CH₃COOC₂H₅
CAS Number: 141-78-6
Specifications:
| Storage Temperature | Ambient | ||
| Product Type | Laboratory Chemical | Forms | Liquid |
| Product Brand | VWR | ||
| Product Grade | HPLC Grade | Formula | CH₃COOC₂H₅ |
VWR Ethyl Acetate ≥99.8%, HiPerSolv CHROMANORM® is a high-purity solvent designed specifically for HPLC (High-Performance Liquid Chromatography), GC (Gas Chromatography), and spectroscopic applications. This solvent is optimized for high sensitivity, low UV absorbance, and minimal impurities, making it ideal for use in analytical laboratories, pharmaceutical industries, environmental testing, and chemical research.
Key Features & Specifications
| Property | Details |
|---|---|
| Chemical Name | Ethyl Acetate |
| Purity | ≥99.8% |
| Brand | VWR HiPerSolv CHROMANORM® |
| Grade | HPLC Grade |
| Molecular Formula | C₄H₈O₂ |
| Molecular Weight | 88.11 g/mol |
| Boiling Point | 77.1°C |
| Density | 0.902 g/cm³ at 20°C |
| UV Cutoff | ≤205 nm |
| Absorbance (at 254 nm) | ≤0.01 AU |
| Absorbance (at 280 nm) | ≤0.005 AU |
| Water Content (Karl Fischer) | ≤0.01% |
| Residual Evaporation Residue | ≤1.0 mg/L |
| Appearance | Clear, colorless liquid |
| Solubility | Miscible with organic solvents, slightly soluble in water |
| Packaging Options | Glass bottles & metal cans (various sizes) |
| Storage Conditions | Store in a cool, dry place, away from direct sunlight and moisture |
Use Cases & Applications
1. High-Performance Liquid Chromatography (HPLC) Analysis
Primary Use:
- HPLC-grade Ethyl Acetate serves as a mobile phase solvent in reverse-phase and normal-phase chromatography.
- Ensures low baseline noise, high reproducibility, and consistent retention times.
Practical Example:
A pharmaceutical laboratory analyzing active pharmaceutical ingredients (APIs) in a drug formulation uses VWR Ethyl Acetate as part of the HPLC mobile phase. Its low UV absorbance ensures accurate quantification of compounds at 254 nm and 280 nm, improving method sensitivity and resolution.
2. Gas Chromatography (GC) Sample Preparation
Primary Use:
- Used as a solvent for sample extraction and dilution in gas chromatography (GC) analysis.
- Ensures high volatility and purity, reducing interference in mass spectrometry (GC-MS) and flame ionization detection (GC-FID).
Practical Example:
An environmental testing lab analyzing pesticide residues in food samples uses VWR Ethyl Acetate for liquid-liquid extraction before injecting the sample into a GC-MS system. The high purity of HiPerSolv CHROMANORM® solvents prevents background contamination, ensuring precise quantification of pesticide residues.
3. Sample Extraction in Pharmaceutical & Chemical Analysis
Primary Use:
- Used as a solvent for solid-liquid and liquid-liquid extraction techniques.
- Efficiently extracts polar and non-polar analytes in drug testing, bioanalysis, and natural product research.
Practical Example:
A forensic laboratory extracts toxic compounds from biological fluids (blood, urine, tissue samples) using ethyl acetate in liquid-liquid extraction (LLE) protocols before analyzing them via LC-MS or GC-MS. Its low impurity profile ensures high analyte recovery and minimal matrix interference.
4. Organic Synthesis & Chemical Reactions
Primary Use:
- Used as a reaction medium in esterification, condensation, and purification steps.
- Facilitates ester synthesis, chromatography purification, and crystallization.
Practical Example:
A chemical research laboratory synthesizing pharmaceutical intermediates uses ethyl acetate as a reaction solvent due to its excellent solvating properties for organic compounds. Post-reaction, it is also used for crystallization and purification to obtain a high-purity final product.
5. Residue Analysis & Food Safety Testing
Primary Use:
- Used in food safety laboratories for analyzing contaminants such as mycotoxins, pesticides, and industrial pollutants.
- Aids in sample cleanup and extraction processes.
Practical Example:
A food quality control laboratory testing aflatoxins in peanuts uses ethyl acetate in solid-phase extraction (SPE) protocols to isolate contaminants before analysis with HPLC-FLD (fluorescence detection). The low residual impurity profile ensures high detection sensitivity.
6. UV-Vis & Spectrophotometric Applications
Primary Use:
- Used as a reference solvent in UV-Vis and fluorescence spectroscopy due to its low UV absorbance.
- Ideal for dissolving analytes in spectroscopic analysis.
Practical Example:
A materials science laboratory analyzing polymer degradation using UV-Vis spectroscopy dissolves polymer samples in VWR Ethyl Acetate to obtain clean absorbance spectra without solvent interference.
Advantages of VWR Ethyl Acetate ≥99.8%, HiPerSolv CHROMANORM®
🔬 Ultra-High Purity (≥99.8%) – Minimizes contaminants that could interfere with analytical results.
⚗ Low UV Absorbance – Ensures high sensitivity in HPLC and spectroscopic applications.
⏳ Consistent & Reproducible – Certified for batch-to-batch uniformity, improving method validation.
🌍 Versatile Applications – Suitable for HPLC, GC, LC-MS, UV-Vis, food safety, pharmaceutical, and chemical synthesis.
🚀 Optimized for Chromatography – Ensures sharp peaks, low baseline noise, and high analytical accuracy.
Storage & Handling Guidelines
- Store in a cool, dry, and well-ventilated area away from heat, sparks, and open flames.
- Keep the container tightly closed to prevent moisture absorption.
- Use proper PPE (gloves, safety goggles, lab coat) when handling.
VWR Ethyl Acetate ≥99.8%, HiPerSolv CHROMANORM® is a high-purity, low-residue solvent designed for precise analytical applications in chromatography, spectroscopy, and sample extraction. Its exceptional purity, stability, and low UV absorbance make it a preferred choice for pharmaceutical, environmental, and research laboratories.
For HPLC, GC, and sample preparation, this solvent ensures accurate, reproducible results, meeting the strictest quality standards for analytical chemistry. 🚀
Specification Test Results
| Assay (GC) | Min. 99.8 % |
| Acidity | Max. 0.0005 meq/g |
| Alkalinity | Max. 0.0002 meq/g |
| Evaporation residue | Max. 5 ppm |
| Water | Max. 0.1 % |
| Absorbance (260 nm) | Max. 0.15 |
| Absorbance (270 nm) | Max. 0.05 |
| Absorbance (300 nm) | Max. 0.02 |
| Transmittance (260 nm) | Min. 70 % |
| Transmittance (270 nm) | Min. 90 % |
| Transmittance (300 nm) | Min. 96 % |