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Thermo Scientific™ Metformin hydrochloride 97%, 5g
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Specifications:
| Application | cell Signalling | ||
| Storage Temperature | Room Temperature | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₄H₁₂ClN₅ |
Metformin hydrochloride is a biguanide-class hypoglycemic agent widely used for glycemic control in type 2 diabetes. It reduces hepatic glucose production (gluconeogenesis), increases insulin sensitivity, and improves peripheral glucose uptake. Unlike sulfonylureas, metformin does not cause insulin release or hypoglycemia and is associated with a low risk of lactic acidosis when dosed appropriately.
Catalog & Pack Information
| Catalog Number | Pack Size | Container Type |
|---|---|---|
| 429720050 | 5 g | Glass bottle |
Chemical Specifications
| Test Parameter | Specification |
|---|---|
| Purity (HPLC) | ≥96.0% |
| Appearance | White crystalline powder |
| Melting Point | 216–224 °C (literature: 218–223 °C) |
| Infrared Spectrum | Conforms to reference standard |
| Solubility | Freely soluble in water, insoluble in organic solvents |
Applications
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Pharmaceutical Analysis
- Used as a reference standard for quantifying metformin in tablets, capsules, and extended-release formulations via HPLC, UPLC, or LC-MS
- Suitable for method development and validation in pharma QC labs
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Research on Diabetes and Metabolism
- Commonly used in in vitro and in vivo studies of glucose metabolism, insulin signaling, and metabolic syndrome
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Food & Beverage Testing
- Certified standard applicable in contaminant detection and nutritional studies
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Cancer Research
- Applied in experimental oncology to study antiproliferative effects, particularly via LKB1-AMPK pathway activation
Biochemical & Physiological Actions
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Mechanism of Action:
- Activates AMPK (AMP-activated protein kinase) via upstream LKB1 kinase
- Inhibits hepatic gluconeogenesis and glucose output
- Increases insulin receptor activity and GLUT4 translocation
- Improves lipid profile and reduces hyperinsulinemia
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Cancer Research Potential:
- Exhibits antiproliferative and pro-apoptotic effects in various tumor cell lines
- Explored for potential repurposing in breast, colon, and pancreatic cancer models
Storage & Handling
- Storage: Store at ambient temperature in a tightly closed container
- Stability: Stable under recommended storage conditions
- Usage: Use proper PPE; avoid inhalation or direct skin contact
Thermo Scientific™ Metformin Hydrochloride (≥96%) offers researchers and quality control analysts a high-quality, certified reference material for pharmaceutical testing, diabetes research, and metabolic pathway investigation. Backed by precise titration and purity standards, it supports reproducibility and compliance in validated analytical methods. Its dual relevance in clinical therapeutics and experimental oncology makes it a versatile tool across multiple scientific domains.