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High-Purity Anticholinergic Agent for Neuroscience and Pharmacological Research
Scopolamine hydrobromide trihydrate is a high-purity salt form of scopolamine, a tropane alkaloid derived from plants in the Solanaceae family (e.g., Hyoscyamus niger, Atropa belladonna). It exhibits potent anti-muscarinic, anti-emetic, and anti-spasmodic activities by competitively blocking muscarinic acetylcholine receptors (mAChRs). Supplied at ≥99% purity, this compound is widely used in neuroscience and pharmacological research—especially in animal models of memory impairment and Alzheimer’s disease.
Key Features & Benefits
- High Purity (≥99%): Suitable for reliable and reproducible research results
- Pharmacologically Relevant: Exhibits potent competitive anti-muscarinic activity
- Animal Model Utility: Frequently used to induce transient cognitive deficits in rodents
- Versatile Applications: Useful in memory, neurodegeneration, and cholinergic signaling research
- Available Formats: Supplied in 1 g, 5 g, and 25 g glass bottles
Chemical & Physical Properties
| Attribute | Details |
|---|---|
| Product Name | Scopolamine Hydrobromide Trihydrate |
| CAS Number | 6533-68-2 |
| Chemical Formula | C₁₇H₂₈BrNO₇ |
| Molecular Weight | 438.32 g/mol |
| Purity | ≥99% |
| Appearance | Colorless to white crystalline powder or crystals |
| Solubility | Soluble in water |
| Specific Optical Rotation | –24° to –27° (c = 5, H₂O at 20 °C, 589 nm) |
| Water Content (Karl Fischer) | 10–13% |
| Assay (Titration with HClO₄) | ≥98.5% |
Applications
- Neuroscience Research: Used to study cholinergic dysfunction and learning and memory pathways
- Alzheimer’s Disease Modeling: Induces cognitive deficits in rodents for behavioral, molecular, and pharmacological testing
- Pharmacology: Characterization of muscarinic receptor subtypes, especially M1 mAChRs
- Toxicology: Used in dose-response studies to evaluate the effects of anti-cholinergic load
- Education & Training: Demonstrates the physiological impact of acetylcholine inhibition
Ordering Information
| Catalog Number | Quantity | Packaging |
|---|---|---|
| 161750010 | 1 g | Glass bottle |
| 161750050 | 5 g | Glass bottle |
| 161750250 | 25 g | Glass bottle |
Safety & Handling
- Storage: Store at room temperature in a dry, ventilated area
- Hazard: Toxic if swallowed or absorbed through skin; use appropriate PPE
- Regulatory Status: For Research Use Only (RUO); not for human or veterinary diagnostic or therapeutic use
Thermo Scientific™ Scopolamine Hydrobromide Trihydrate, 99% is a trusted and widely used research compound for exploring central nervous system pharmacology, cholinergic receptor dynamics, and memory-related disorders. With excellent purity and detailed specification control, it is the ideal tool for laboratories conducting Alzheimer’s disease research, behavioral neuroscience, and receptor pharmacology.
No resources are currently available for this product.
High-Purity Anticholinergic Agent for Neuroscience and Pharmacological Research
Scopolamine hydrobromide trihydrate is a high-purity salt form of scopolamine, a tropane alkaloid derived from plants in the Solanaceae family (e.g., Hyoscyamus niger, Atropa belladonna). It exhibits potent anti-muscarinic, anti-emetic, and anti-spasmodic activities by competitively blocking muscarinic acetylcholine receptors (mAChRs). Supplied at ≥99% purity, this compound is widely used in neuroscience and pharmacological research—especially in animal models of memory impairment and Alzheimer’s disease.
Key Features & Benefits
- High Purity (≥99%): Suitable for reliable and reproducible research results
- Pharmacologically Relevant: Exhibits potent competitive anti-muscarinic activity
- Animal Model Utility: Frequently used to induce transient cognitive deficits in rodents
- Versatile Applications: Useful in memory, neurodegeneration, and cholinergic signaling research
- Available Formats: Supplied in 1 g, 5 g, and 25 g glass bottles
Chemical & Physical Properties
| Attribute | Details |
|---|---|
| Product Name | Scopolamine Hydrobromide Trihydrate |
| CAS Number | 6533-68-2 |
| Chemical Formula | C₁₇H₂₈BrNO₇ |
| Molecular Weight | 438.32 g/mol |
| Purity | ≥99% |
| Appearance | Colorless to white crystalline powder or crystals |
| Solubility | Soluble in water |
| Specific Optical Rotation | –24° to –27° (c = 5, H₂O at 20 °C, 589 nm) |
| Water Content (Karl Fischer) | 10–13% |
| Assay (Titration with HClO₄) | ≥98.5% |
Applications
- Neuroscience Research: Used to study cholinergic dysfunction and learning and memory pathways
- Alzheimer’s Disease Modeling: Induces cognitive deficits in rodents for behavioral, molecular, and pharmacological testing
- Pharmacology: Characterization of muscarinic receptor subtypes, especially M1 mAChRs
- Toxicology: Used in dose-response studies to evaluate the effects of anti-cholinergic load
- Education & Training: Demonstrates the physiological impact of acetylcholine inhibition
Ordering Information
| Catalog Number | Quantity | Packaging |
|---|---|---|
| 161750010 | 1 g | Glass bottle |
| 161750050 | 5 g | Glass bottle |
| 161750250 | 25 g | Glass bottle |
Safety & Handling
- Storage: Store at room temperature in a dry, ventilated area
- Hazard: Toxic if swallowed or absorbed through skin; use appropriate PPE
- Regulatory Status: For Research Use Only (RUO); not for human or veterinary diagnostic or therapeutic use
Thermo Scientific™ Scopolamine Hydrobromide Trihydrate, 99% is a trusted and widely used research compound for exploring central nervous system pharmacology, cholinergic receptor dynamics, and memory-related disorders. With excellent purity and detailed specification control, it is the ideal tool for laboratories conducting Alzheimer’s disease research, behavioral neuroscience, and receptor pharmacology.
No resources are currently available for this product.
![[DRE-A16914920AL-100] LGC Scopolamine (Hyoscine), 100 µg/mL in Acetonitrile (ISO 17034), 1 mL](/web/image/product.product/49717/image_512/%5BDRE-A16914920AL-100%5D%20LGC%20Scopolamine%20%28Hyoscine%29%2C%20100%20%C2%B5g-mL%20in%20Acetonitrile%20%28ISO%2017034%29%2C%201%20mL%20?unique=96c5da2)
Specifications
| Pack Size | 1g, 5g, 25g |