Thermo Scientific™ Melatonin, 99%

Thermo Scientific™ Melatonin (≥99%) is a neurohormone naturally produced by the pineal gland, regulating sleep-wake cycles, circadian rhythms, and stress responses.

In research settings, it is utilized for its antioxidant, neuroprotective, anti-inflammatory, and anti-apoptotic properties. Melatonin also functions as an inhibitor of neuronal nitric oxide synthase (nNOS) and an activator of melatonin receptors MEL-1A-R and MEL-1B-R.

This compound exhibits endogenous antioxidant and immunomodulatory activity, making it valuable in studies of aging, oxidative stress, cancer, and neurodegenerative disorders.

Key Features

• High Purity: >99% (HPLC) for reproducible biological performance.
• Biologically Active Hormone: Regulates circadian rhythm and sleep-wake cycles.
• Antioxidant and Anti-Apoptotic: Upregulates antioxidant enzymes, inhibits nNOS, and protects against oxidative stress.
• Receptor Modulator: Activates melatonin receptors MEL-1A-R and MEL-1B-R.
• Dual Role: Inhibits apoptosis in immune and neural cells while inducing apoptosis in certain cancer cells.
• Light-Sensitive: Store protected from light, in a tightly sealed container.
• Research Use Only (RUO): Not for human or veterinary use.

Chemical Identifiers

Specifications

Applications

• Neurobiology: Study of circadian rhythm regulation and sleep-wake mechanisms.
• Pharmacology: Investigations on receptor binding (MEL-1A-R and MEL-1B-R).
• Oncology: Modulation of apoptosis and metastasis inhibition in breast cancer cells.
• Oxidative Stress Research: Regulation of antioxidant enzymes and ROS scavenging.
• Aging and Immunology: Research on neuroprotection and immune cell regulation.
• Endocrinology: Study of hormonal control in stress and circadian signaling.

References

1. Borin, T.F. et al. “Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1.” J. Pineal Res. (2016) 60(1), 3–15.
2. Tan, D.X. et al. “Melatonin: A hormone, tissue factor, and antioxidant vitamin.” J. Pineal Res. (2003) 34(1), 75–78.
3. Dubocovich, M.L. et al. “Pharmacology and function of melatonin receptors.” FASEB J. (1988) 2(12), 2765–73.
4. Reiter, R.J. et al. “Mechanisms for the protective actions of melatonin in the CNS.” Ann. N.Y. Acad. Sci. (2001) 939, 200–15.

Safety & Handling

• Signal Word: Danger
• Hazard Statements:
  • H301 – Toxic if swallowed
  • H341 – Suspected of causing genetic defects
• Precautionary Statements:
  • P201 – Obtain special instructions before use
  • P280 – Wear protective gloves and eye protection
  • P301 + P330 + P331 – IF SWALLOWED: Rinse mouth. Do NOT induce vomiting
  • P308 + P313 – If exposed, get medical advice
• Classification: Acute Oral Toxicity Cat. 3 | Germ Cell Mutagenicity Cat. 2

The Thermo Scientific™ Melatonin (≥99%) is a research-grade neurohormone essential for studies of circadian rhythm, oxidative stress, apoptosis, and receptor-mediated signaling.

Its high purity, broad biological activity, and reliable Thermo Scientific quality make it ideal for neurobiology, pharmacology, oncology, and endocrinology research.