Thermo Scientific™ Diethylaminoethyl dextran

DEAE-Dextran is used in the development of sustained release protein delivery and nucleic acid transfection systems. It has been speculated that DEAE-Dextran may cause a stimulation of the helper T-cell function in antibody synthesis.

Applications

DEAE-Dextran is used in the development of sustained release protein delivery and nucleic acid transfection systems. The use of DEAE-Dextran as an efficient adjuvant in vaccine production is well established. For instance, DEAE-Dextran has been used for immunization of guinea pigs and swine with inactivated foot-and-mouth disease and rhesus monkeys with inactivated Venezulean equine encephalomyelitis virus, IVEE. The mechanism of action of DEAE-Dextran is not clear. The effect on the humoral response of rhesus monkeys to IVEE vaccine results in a typical IgM-IgG response. It has been speculated that DEAE-Dextran may cause a stimulation of the helper T-cell function in antibody synthesis.

Solubility

Soluble in water.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

RUO – Research Use Only

General References:

1. James H. McCutchan,; Joseph S. Pagano. Enhancement of the Infectivity of Simian Virus 40 Deoxyribonucleic Acid With Diethylaminoethyl-Dextran2. J Natl Cancer Inst. 1968, 41 (2),351-357..
2. H Duc-Nguyen. Enhancing effect of diethylaminoethyl-dextran on the focus-forming titer of a murine sarcoma virus (Harvey strain). J Virol. 1968, 2 (6), 643-644.