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Specifications:
| Application | Analytical Chemistry, Organic Synthesis | ||
| Storage Temperature | Ambient | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | H₂NC₆H₄SO₂NH₂ |
Sulfanilamide is a synthetic sulfonamide antibacterial compound with broad applications in biochemical research and synthetic chemistry. It acts as a competitive inhibitor of dihydropteroate synthase, an enzyme involved in folic acid biosynthesis in bacteria, making it a well-characterized antimicrobial agent.
This high-purity, research-grade compound is supplied by Thermo Scientific™ Chemicals for Research Use Only (RUO) and is also valued as a versatile intermediate in organic synthesis, especially for the production of 2,6-disubstituted anilines.
Key Features & Benefits
-
≥98% Purity (HPLC Assay)
Ensures consistent results in analytical and synthetic applications. -
Proven Antimicrobial Mechanism
Inhibits bacterial folic acid biosynthesis via dihydropteroate synthase. -
Synthetic Intermediate
Commonly used in electrophilic substitution reactions followed by desulfonation. -
Broad Solubility Profile
Soluble in water, ethanol, acetone, glycerol, and propylene glycol. -
RUO Grade
Suitable for laboratory, academic, and industrial research—not for clinical use.
Chemical Identity & Properties
| Property | Value |
|---|---|
| IUPAC Name | 4-aminobenzene-1-sulfonamide |
| Synonyms | Sulfanilamide, sulphonamide, streptocid, P-anilinesulfonamide |
| Molecular Formula | C₆H₈N₂O₂S |
| Molecular Weight | 172.20 g/mol |
| Appearance | White crystals, powder, crystalline powder, or fused solid |
| Purity | ≥97.5% (HPLC) |
| Melting Point | 162.0–168.0°C |
| Solubility | Soluble in water, acetone, ethanol, glycerol, propylene glycol, and HCl; insoluble in chloroform, ether, benzene, and petroleum ether |
| Storage Conditions | Store in a cool, dry place; incompatible with strong oxidizers |
| InChI Key | FDDDEECHVMSUSB-UHFFFAOYSA-N |
| SMILES | NC1=CC=C(C=C1)S(N)(=O)=O |
Applications & Uses
-
Antibacterial Research
- Investigate folate biosynthesis inhibition in bacteria
- Used in studies of sulfonamide resistance mechanisms
-
Organic Synthesis
- Intermediate for preparation of 2,6-disubstituted anilines
- Functions as a sulfonamide blocking group in synthetic pathways
-
Analytical Chemistry
- Used in electrophoresis, chromatographic assays, and as a derivatization reagent
- Referenced in capillary electrophoresis and contactless conductivity detection studies
-
Histochemical Applications
- Diazotized sulfanilamide used in catechin-specific staining procedures
Safety & Handling
-
Hazard Classification:
Avoid inhalation, ingestion, and contact with skin or eyes. Use appropriate PPE (gloves, goggles, lab coat). -
Storage:
Store tightly sealed in a cool, dry, well-ventilated place. Keep away from strong oxidizing agents. -
Use Restrictions:
For Research Use Only. Not for drug, food, or household use.
References
- Org. Synth. Coll., 3, 262 (1955) – Use in electrophilic substitution
- Food Chem., 2015, 188, 446–451 – Detection in food samples
- Biotech. Histochem., 2015, 90(1), 45–54 – Histochemical reagent application
Thermo Scientific™ Sulfanilamide (98%) is a reliable and well-characterized sulfonamide compound ideal for biochemical inhibition studies, intermediate use in synthetic chemistry, and analytical method development. With its high purity, excellent solubility, and broad research utility, it remains a cornerstone compound in both microbiological and organic chemistry applications.
- Pack Size: 100g 500g 2.5 Kg