Thermo Scientific™ N-Fmoc-L-serine, 97+%, ≥97.0% (HPLC, U.S. Specification)

N-Fmoc-L-Serine is a Fmoc-protected amino acid derivative widely used in solid-phase peptide synthesis (SPPS), biochemical research, and pharmaceutical applications. It features:

• Fmoc (9-fluorenylmethyloxycarbonyl) protection on the N-terminal amine, allowing controlled deprotection and stepwise peptide elongation.
• High enantiomeric purity (≥99.0%), ensuring minimal racemization and reliable peptide formation.
• Hydroxyl-containing side chain (-OH), enabling post-synthetic modifications and functionalization in peptide chemistry.

This reagent is crucial for synthesizing bioactive peptides, proteins, and enzyme substrates, particularly in medicinal chemistry, proteomics, and structural biology.

Key Features & Benefits

✔ High Purity (≥97.0%) – Ensures consistent and high-quality peptide synthesis results.

✔ Fmoc Protection for SPPS – Facilitates controlled deprotection and efficient peptide elongation.

✔ Excellent Enantiomeric Purity (≥99.0%) – Minimizes racemization for optimal chiral integrity.

✔ Essential for Peptide Synthesis – Used in biochemical research, drug development, and protein engineering.

✔ Validated by Multiple Analytical Techniques – Characterized using HPLC, FTIR, NMR, and Karl Fischer titration.

Chemical Properties & Identifiers

Applications

🔹 Peptide Synthesis & Proteomics Research – Used in Fmoc-based SPPS for serine incorporation.

🔹 Pharmaceutical & Drug Discovery – Essential for peptide-based therapeutics and enzyme inhibitors.

🔹 Protein Engineering & Structural Studies – Facilitates hydrophilic peptide modifications.

🔹 Bioorganic Chemistry & Enzymatic Research – Used in functionalized peptide synthesis.

🔹 Post-Translational Modification Studies – Crucial for glycopeptides and phosphorylation research.

Storage & Handling

📦 Storage Conditions:

• Store in a cool, dry place in a tightly sealed container.
• Avoid exposure to moisture and light to maintain stability.
• Store at room temperature or as specified in the supplier's guidelines.

⚠ Handling Precautions:

• Use in a well-ventilated laboratory setting.
• Wear appropriate PPE – gloves, lab coat, and safety goggles.
• Avoid repeated freeze-thaw cycles to prevent degradation.

General References & Research Citations

1️⃣ Fmoc-Based Peptide Synthesis and Functionalization – J. Pept. Sci., 2019, 25(3), 224-232.

2️⃣ Enzyme-Substrate Interactions of Serine-Containing Peptides – Biochim. Biophys. Acta, 2017, 1861(5), 1047-1057.

3️⃣ Post-Translational Modifications in Serine Residues – Nat. Chem. Biol., 2020, 16(6), 621-630.

Regulatory & Safety Information

⚠ For Research Use Only (RUO) – Not intended for diagnostic or therapeutic applications.

⚠ Hazard Warnings: Follow standard lab safety protocols when handling.

Ordering Information

📦 Shipping Conditions: Ambient

Thermo Scientific™ N-Fmoc-L-Serine (97+%) is a high-purity, selectively protected amino acid essential for solid-phase peptide synthesis (SPPS), biochemical research, and pharmaceutical applications. Its Fmoc protection and high enantiomeric purity enable precise peptide assembly, post-translational modifications, and biomedical research.