Thermo Scientific™ N-Fmoc-L-glutamic acid, 95%, HPLC

Thermo Scientific™ N-Fmoc-L-Glutamic Acid (95%) is a high-purity, nonessential amino acid derivative commonly used in peptide synthesis, biochemical research, and pharmaceutical development. This Fmoc-protected glutamic acid plays a crucial role in solid-phase peptide synthesis (SPPS), providing selectivity in amide bond formation.

Glutamic acid is a key neurotransmitter in the central nervous system, essential for neuronal signaling and metabolic processes. This compound is also used in neurobiology studies, drug design, and protein engineering. Additionally, N-Fmoc-L-Glutamic Acid has been explored in the treatment of liver disease-associated encephalopathy due to its role in ammonia detoxification.

This product was originally part of the Alfa Aesar portfolio and has now been integrated into the Thermo Scientific Chemicals product line, ensuring continued high-quality standards.

Key Features & Benefits

✔ High Purity (≥95%) – Ensures reliability in peptide synthesis and biochemical research.

✔ Fmoc-Protected Amino Acid – Essential for solid-phase peptide synthesis (SPPS).

✔ Biologically Relevant – Plays a role in neurotransmission and metabolic pathways.

✔ Versatile Applications – Used in protein engineering, medicinal chemistry, and drug development.

✔ Stable & Well-Characterized – Molecular structure validated by HPLC assay (>94%).

Chemical Properties & Identifiers

Applications

🔹 Peptide Synthesis & Proteomics – Used in Fmoc-based solid-phase peptide synthesis (SPPS) for selective deprotection and peptide elongation.

🔹 Neurobiology & Neurotransmitter Studies – Investigated for its role in synaptic transmission and neuronal metabolism.

🔹 Pharmaceutical Research & Drug Design – Utilized in medicinal chemistry to study peptide-drug interactions.

🔹 Enzymatic & Metabolic Studies – Involved in folate metabolism and amino acid biochemistry.

🔹 Liver Disease & Encephalopathy Research – Studied for its potential therapeutic role in hepatic coma.

🔹 Self-Assembly & Supramolecular Chemistry – Utilized in nanomaterials and biomolecular engineering.

Storage & Handling

📦 Storage Conditions:

• Store at cool, dry conditions in a tightly sealed container.
• Ensure adequate ventilation when handling.
• Keep away from oxidizing agents to maintain stability.

⚠ Handling Precautions:

• Use in a well-ventilated area.
• Wear appropriate PPE – gloves, lab coat, and eye protection.
• Dispose of waste properly according to local regulations.

General References & Research Citations

1️⃣ Tomsho JW et al. – Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-γ-glutamates: Kinetics of multiple glutamate ligations catalyzed by folylpoly-γ-glutamate synthetase. Organic & Biomolecular Chemistry, 2005, 3(18), 3388-3398.

2️⃣ Yuko Kamikawa et al. – Self-Assembly of Folic Acid Derivatives: Induction of Supramolecular Chirality by Hierarchical Chiral Structures. Chemistry - A European Journal, 2004, 10(23), 5942-5951.

Regulatory & Safety Information

⚠ For Research Use Only (RUO) – Not intended for diagnostic or therapeutic applications.

⚠ Hazard Warnings: Follow standard lab safety procedures.

Ordering Information

📦 Shipping Conditions: Ambient

Thermo Scientific™ N-Fmoc-L-Glutamic Acid (95%) is a high-purity, Fmoc-protected amino acid essential for peptide synthesis, neurobiology, and pharmaceutical research. With its high chemical stability, reliable assay validation, and broad scientific applications, this compound is a critical reagent in synthetic and biomedical research.