Thermo Scientific™ Lumefantrine 98%

Lumefantrine 98% is a high-purity pharmaceutical compound used primarily in the treatment of malaria. It is commonly employed in combination with artemether in artemisinin-based combination therapies (ACTs), making it a vital component in the treatment of uncomplicated malaria caused by Plasmodium falciparum. Lumefantrine 98% is known for its high chemical stability, purity, and effectiveness in combating malarial infections.

Chemical Identifiers

• CAS Number: 82186-77-4
• IUPAC Name: 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl]ethan-1-ol
• Molecular Formula: C30H32Cl3NO
• InChI Key: DYLGFOYVTXJFJP-MYYYXRDXNA-N
• SMILES: CCCCN(CCCC)CC(O)C1=CC(Cl)=CC2=C1C1=CC=C(Cl)C=C1\C2=C\C1=CC=C(Cl)C=C1
• Molecular Weight: 528.94 g/mol
• Synonyms: Lumefantrine, dl-benflumelol, benflumetol, Coartem

Key Features and Benefits

• High Purity:
  Lumefantrine 98% offers a purity of ≥97.5% as determined by HPLC, ensuring consistent quality and reliable performance in pharmaceutical formulations.
• Effective Malaria Treatment:
  Lumefantrine is commonly used in combination with artemether as part of ACTs (Artemisinin-based Combination Therapies), a first-line treatment for uncomplicated malaria. The combination of these two compounds works synergistically to clear malaria parasites in infected individuals.
• Appearance:
  The compound appears as a yellow powder or crystalline powder, making it easy to handle and incorporate into pharmaceutical preparations.
• Chemical Stability:
  Lumefantrine 98% is chemically stable, with a melting point between 128°C to 134°C, ensuring consistent properties during storage and use.
• Non-Volatile with Low Moisture Content:
  The loss on drying is <2%, indicating that moisture content is minimal and does not affect the compound’s stability or efficacy.
• Infrared Spectrum:
  The compound conforms to the infrared spectrum, ensuring the integrity and purity of the product for pharmaceutical formulations.

Applications

• Malaria Treatment:
  Lumefantrine is a key ingredient in artemether-lumefantrine combination therapy, used to treat uncomplicated Plasmodium falciparum malaria. It is part of a combination therapy that is recommended by the World Health Organization (WHO) for the treatment of malaria in regions where drug-resistant malaria strains are prevalent.
• Pharmaceutical Research:
  Lumefantrine 98% is widely used in research to develop new malaria treatments and improve the efficacy of existing therapies. It is also used in drug formulation and clinical trials for malaria medications.
• Antimalarial Drug Development:
  It plays a critical role in antimalarial drug development due to its synergistic action when combined with artemisinin derivatives.

Specifications

Storage and Handling

• Storage:
  Store Lumefantrine 98% at room temperature in a cool, dry place. Protect it from light and moisture to maintain its chemical stability.
• Handling:
  Protective gloves and appropriate lab safety equipment should be worn when handling Lumefantrine 98%. Ensure that the compound is used in compliance with local safety guidelines for pharmaceutical handling.

Thermo Scientific™ Lumefantrine 98% is a high-purity, effective compound used in combination therapies for treating uncomplicated malaria. With its high chemical stability, low moisture content, and precise formulation, it is ideal for pharmaceutical applications and research purposes. Whether you're developing new antimalarial drugs or working on improving combination therapies, Lumefantrine 98% provides the necessary efficacy and consistency required in malaria treatment.